Literature DB >> 16320210

New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical.

H M Ge1, Y C Song, C Y Shan, Y H Ye, R X Tan.   

Abstract

In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem of Imperata cylindrical (Gramineae). Structure determination of pleospdione was accomplished using IR, HR-ESI-MS, 1D and 2D NMR spectral analysis. Compounds 4 - 6 exhibited significant cytotoxic activity against human colon cancer (SW1116) and leukemia (K562) cell lines while compounds 1, 2 and 7 were only weakly or moderately active.

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Year:  2005        PMID： 16320210     DOI： 10.1055/s-2005-864190

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

1.  Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370.

Authors:  Xiaoping Pan; Haixia Wang; Dongmeng Tong; Chen Wang; Li Sun; Chunjuan Zhao; Yan Li; Lida Zhu; Di Wu
Journal:  Am J Cancer Res       Date:  2016-12-01       Impact factor: 6.166

2.  Highly oxygenated angucycline from Streptomyces sp. KCB15JA014.

Authors:  Gil Soo Kim; Geum Jin Kim; Byeongsan Lee; Tae Hoon Oh; Mincheol Kwon; Jung-Sook Lee; Jun-Pil Jang; Hyukjae Choi; Sung-Kyun Ko; Young-Soo Hong; Jae-Hyuk Jang; Jong Seog Ahn
Journal:  J Antibiot (Tokyo)       Date:  2020-07-10       Impact factor: 2.649

3.  Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells.

Authors:  Wenjun Liu; Juan He; Yiling Yang; Qulian Guo; Fei Gao
Journal:  Am J Cancer Res       Date:  2016-11-01       Impact factor: 6.166

Review 4.  Diverse host-associated fungal systems as a dynamic source of novel bioactive anthraquinones in drug discovery: Current status and future perspectives.

Authors:  Zeinab T Shakour; Mohamed A Farag
Journal:  J Adv Res       Date:  2021-11-22       Impact factor: 12.822

5.  Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma.

Authors:  Ming-Jie Pang; Zhun Yang; Xing-Lin Zhang; Zhao-Fang Liu; Jun Fan; Hong-Ying Zhang
Journal:  Acta Pharmacol Sin       Date:  2016-10-03       Impact factor: 6.150

Review 6.  Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities.

Authors:  Mireille Fouillaud; Mekala Venkatachalam; Emmanuelle Girard-Valenciennes; Yanis Caro; Laurent Dufossé
Journal:  Mar Drugs       Date:  2016-03-25       Impact factor: 5.118

7.  Anti-mycobacterial activity of marine fungus-derived 4-deoxybostrycin and nigrosporin.

Authors:  Cong Wang; Juan Wang; Yuhong Huang; Hong Chen; Yan Li; Lili Zhong; Yi Chen; Shengping Chen; Jun Wang; Juling Kang; Yi Peng; Bin Yang; Yongcheng Lin; Zhigang She; Xiaomin Lai
Journal:  Molecules       Date:  2013-01-29       Impact factor: 4.411

Review 8.  Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges.

Authors:  Archana Singh; Dheeraj K Singh; Ravindra N Kharwar; James F White; Surendra K Gond
Journal:  Microorganisms       Date:  2021-01-19

9.  Synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxybostrycin.

Authors:  Hong Chen; Xun Zhu; Li-Li Zhong; Bing Yang; Jia Li; Jue-Heng Wu; Sheng-Ping Chen; Yong-Cheng Lin; Yuhua Long; Zhi-Gang She
Journal:  Mar Drugs       Date:  2012-11-30       Impact factor: 5.118
  9 in total

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