Literature DB >> 27904770

Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells.

Wenjun Liu1, Juan He1, Yiling Yang1, Qulian Guo1, Fei Gao1.   

Abstract

The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-resistant K562 cells and the overexpression of miR-146a in K562/ADM cells could restore the sensitivity to adriamycin (ADM). In addition, our results showed that the downregulation of miR-146a was associated with increase in CXCR4 expression, which was a direct target of miR-146a. Moreover, our findings also provided experimental evidence that physcion could enhance the anti-proliferative effect of ADM in K562/ADM cells by upregulating miR-146a. In conclusion, this present study showed that miR-146a conferred ADM resistance in CML cells and physcion could improve the sensitivity of K562/ADM cells by enhancing apoptosis via upregulating miR-146a.

Entities:  

Keywords:  CXCR4; chronic myeloid leukemia; drug resistance; miR-146a; physcion

Year:  2016        PMID： 27904770      PMCID： PMC5126272     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  47 in total

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  2 in total

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Journal:  Front Plant Sci       Date:  2019-10-18       Impact factor: 5.753

2.  MicroRNA‑145 promotes the apoptosis of leukemic stem cells and enhances drug‑resistant K562/ADM cell sensitivity to adriamycin via the regulation of ABCE1.

Authors:  Zhijun Wuxiao; Hua Wang; Qunhao Su; Haiyan Zhou; Min Hu; Shi Tao; Lu Xu; Yu Chen; Xinbao Hao
Journal:  Int J Mol Med       Date:  2020-07-15       Impact factor: 4.101
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