Literature DB >> 16311604

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.

Gang Chen1, Hua Qian, Thomas Starzl, Hongtao Sun, Bertha Garcia, Ximo Wang, Yishai Wise, Yuanqing Liu, Ying Xiang, Laura Copeman, Weihua Liu, Anthony Jevnikar, William Wall, David K C Cooper, Noriko Murase, Yifan Dai, Wanyu Wang, Yuliang Xiong, David J White, Robert Zhong.   

Abstract

We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16311604      PMCID： PMC3018862          DOI： 10.1038/nm1330

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  13 in total

1.  Three-month survival of HDAFF transgenic pig hearts transplanted into primates.

Authors:  F N Bhatti; M Schmoeckel; A Zaidi; E Cozzi; G Chavez; M Goddard; J J Dunning; J Wallwork; D J White
Journal:  Transplant Proc       Date:  1999 Feb-Mar       Impact factor: 1.066

2.  Tolerogenic immunosuppression for organ transplantation.

Authors:  Thomas E Starzl; Noriko Murase; Kareem Abu-Elmagd; Edward A Gray; Ron Shapiro; Bijan Eghtesad; Robert J Corry; Mark L Jordan; Paulo Fontes; Tim Gayowski; Geoffrey Bond; Velma P Scantlebury; Santosh Potdar; Parmjeet Randhawa; Tong Wu; Adriana Zeevi; Michael A Nalesnik; Jennifer Woodward; Amadeo Marcos; Massimo Trucco; Anthony J Demetris; John J Fung
Journal:  Lancet       Date:  2003-05-03       Impact factor: 79.321

Review 3.  Clinical trials: where are we now?

Authors:  Stuart J Knechtle
Journal:  Immunol Rev       Date:  2003-12       Impact factor: 12.988

4.  Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.

Authors:  Kenji Kuwaki; Yau-Lin Tseng; Frank J M F Dor; Akira Shimizu; Stuart L Houser; Todd M Sanderson; Courtney J Lancos; Derek D Prabharasuth; Jane Cheng; Kathleen Moran; Yosuke Hisashi; Nicolas Mueller; Kazuhiko Yamada; Julia L Greenstein; Robert J Hawley; Clive Patience; Michel Awwad; Jay A Fishman; Simon C Robson; Henk-Jan Schuurman; David H Sachs; David K C Cooper
Journal:  Nat Med       Date:  2004-12-26       Impact factor: 53.440

5.  Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.

Authors:  Kazuhiko Yamada; Koji Yazawa; Akira Shimizu; Takehiro Iwanaga; Yosuke Hisashi; Matthew Nuhn; Patricia O'Malley; Shuji Nobori; Parsia A Vagefi; Clive Patience; Jay Fishman; David K C Cooper; Robert J Hawley; Julia Greenstein; Henk-Jan Schuurman; Michel Awwad; Megan Sykes; David H Sachs
Journal:  Nat Med       Date:  2004-12-26       Impact factor: 53.440

6.  The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts.

Authors:  S S Lin; M J Hanaway; G V Gonzalez-Stawinski; C L Lau; W Parker; R D Davis; G W Byrne; L E Diamond; J S Logan; J L Platt
Journal:  Transplantation       Date:  2000-12-27       Impact factor: 4.939

7.  Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.

Authors:  Y Xu; T Lorf; T Sablinski; P Gianello; M Bailin; R Monroy; T Kozlowski; M Awwad; D K Cooper; D H Sachs
Journal:  Transplantation       Date:  1998-01-27       Impact factor: 4.939

8.  Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

Authors:  Liangxue Lai; Donna Kolber-Simonds; Kwang-Wook Park; Hee-Tae Cheong; Julia L Greenstein; Gi-Sun Im; Melissa Samuel; Aaron Bonk; August Rieke; Billy N Day; Clifton N Murphy; David B Carter; Robert J Hawley; Randall S Prather
Journal:  Science       Date:  2002-01-03       Impact factor: 47.728

9.  Production of alpha 1,3-galactosyltransferase-deficient pigs.

Authors:  Carol J Phelps; Chihiro Koike; Todd D Vaught; Jeremy Boone; Kevin D Wells; Shu-Hung Chen; Suyapa Ball; Susan M Specht; Irina A Polejaeva; Jeff A Monahan; Pete M Jobst; Sugandha B Sharma; Ashley E Lamborn; Amy S Garst; Marilyn Moore; Anthony J Demetris; William A Rudert; Rita Bottino; Suzanne Bertera; Massimo Trucco; Thomas E Starzl; Yifan Dai; David L Ayares
Journal:  Science       Date:  2002-12-19       Impact factor: 47.728

10.  Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

Authors:  D K Cooper; A H Good; E Koren; R Oriol; A J Malcolm; R M Ippolito; F A Neethling; Y Ye; E Romano; N Zuhdi
Journal:  Transpl Immunol       Date:  1993       Impact factor: 1.708
View more
  114 in total

1.  Pathologic characteristics of transplanted kidney xenografts.

Authors:  Akira Shimizu; Kazuhiko Yamada; Simon C Robson; David H Sachs; Robert B Colvin
Journal:  J Am Soc Nephrol       Date:  2011-11-23       Impact factor: 10.121

Review 2.  CD47 in xenograft rejection and tolerance induction.

Authors:  Yong-Guang Yang
Journal:  Xenotransplantation       Date:  2010 Jul-Aug       Impact factor: 3.907

Review 3.  Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases.

Authors:  Jing Yao; Jiaojiao Huang; Jianguo Zhao
Journal:  Hum Genet       Date:  2016-07-18       Impact factor: 4.132

4.  Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes.

Authors:  Jose L Estrada; Greg Martens; Ping Li; Andrew Adams; Kenneth A Newell; Mandy L Ford; James R Butler; Richard Sidner; Matt Tector; Joseph Tector
Journal:  Xenotransplantation       Date:  2015-03-01       Impact factor: 3.907

Review 5.  Which anti-platelet therapies might be beneficial in xenotransplantation?

Authors:  Moritz Schmelzle; Peter J Cowan; Simon C Robson
Journal:  Xenotransplantation       Date:  2011 Mar-Apr       Impact factor: 3.907

Review 6.  Xenotransplantation--the future of corneal transplantation?

Authors:  Hidetaka Hara; David K C Cooper
Journal:  Cornea       Date:  2011-04       Impact factor: 2.651

Review 7.  Immune response to biologic scaffold materials.

Authors:  Stephen F Badylak; Thomas W Gilbert
Journal:  Semin Immunol       Date:  2008-02-20       Impact factor: 11.130

8.  The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation.

Authors:  Davide Ricci; Henry D Tazelaar; Naoto Miyagi; Vinay P Rao; Rachel A Pedersen; Walter K Kremers; Guerard W Byrne; Christopher G A McGregor
Journal:  J Heart Lung Transplant       Date:  2007-10       Impact factor: 10.247

9.  Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.

Authors:  Guerard W Byrne; Paul G Stalboerger; Eduardo Davila; Carrie J Heppelmann; Mozammel H Gazi; Hugh C J McGregor; Peter T LaBreche; William R Davies; Vinay P Rao; Keiji Oi; Henry D Tazelaar; John S Logan; Christopher G A McGregor
Journal:  Xenotransplantation       Date:  2008 Jul-Aug       Impact factor: 3.907

10.  Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.

Authors:  Mohamed B Ezzelarab; Burcin Ekser; Gabriel Echeverri; Hidetaka Hara; Corin Ezzelarab; Cassandra Long; Pietro Bajona; Bertha Garcia; Noriko Murase; David Ayares; David K C Cooper
Journal:  Xenotransplantation       Date:  2012 Jul-Aug       Impact factor: 3.907
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.