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Literature DB >> 16311336

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.

Peter W Reddien¹, Néstor J Oviedo, Joya R Jennings, James C Jenkin, Alejandro Sánchez Alvarado.

Abstract

We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins that belong to the Argonaute/PIWI protein family and that share highest homology with those proteins defined by Drosophila PIWI. RNA interference (RNAi) of smedwi-2 blocks regeneration, even though neoblasts are present, irradiation-sensitive, and capable of proliferating in response to wounding; smedwi-2(RNAi) neoblast progeny migrate to sites of cell turnover but, unlike normal cells, fail at replacing aged tissue. We suggest that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promote regeneration and homeostasis.

Entities: Gene Species

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Year: 2005 PMID： 16311336 DOI： 10.1126/science.1116110

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

240 in total

Review 1. Small RNAs have a big impact on regeneration.

Authors: Elizabeth J Thatcher; James G Patton
Journal: RNA Biol Date: 2010-05-14 Impact factor: 4.652

2. Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.

Authors: Thomas C J Tan; Ruman Rahman; Farah Jaber-Hijazi; Daniel A Felix; Chen Chen; Edward J Louis; Aziz Aboobaker
Journal: Proc Natl Acad Sci U S A Date: 2012-02-27 Impact factor: 11.205

3. Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development.

Authors: Wendy S Beane; Ai-Sun Tseng; Junji Morokuma; Joan M Lemire; Michael Levin
Journal: Stem Cells Dev Date: 2012-03-23 Impact factor: 3.272

4. Mitochondrial pathway of apoptosis is ancestral in metazoans.

Authors: Cheryl E Bender; Patrick Fitzgerald; Stephen W G Tait; Fabien Llambi; Gavin P McStay; Douglas O Tupper; Jason Pellettieri; Alejandro Sánchez Alvarado; Guy S Salvesen; Douglas R Green
Journal: Proc Natl Acad Sci U S A Date: 2012-03-13 Impact factor: 11.205

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.

Review 1. Small RNAs have a big impact on regeneration.

2. Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.

3. Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development.

4. Mitochondrial pathway of apoptosis is ancestral in metazoans.

5. A regulatory program for excretory system regeneration in planarians.

6. A functional genomic screen in planarians identifies novel regulators of germ cell development.

7. A conserved germline multipotency program.

Review 8. DNA damage and tissue repair: What we can learn from planaria.

9. Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians.

10. The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians.