Literature DB >> 16309903

Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines.

Xu Hui1, Julie Desrivot, Christian Bories, Philippe M Loiseau, Xavier Franck, Reynald Hocquemiller, Bruno Figadère.   

Abstract

A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).

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Year:  2005        PMID： 16309903     DOI： 10.1016/j.bmcl.2005.11.025

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

Review 1.  Natural and synthetic compound anti-Trichomonas vaginalis: an update review.

Authors:  Patrícia de Brum Vieira; Raquel Brandt Giordani; Alexandre José Macedo; Tiana Tasca
Journal:  Parasitol Res       Date:  2015-02-18       Impact factor: 2.289

2.  Activities of Quinoxaline, Nitroquinoxaline, and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni.

Authors:  Stefan L Debbert; Mikaela J Hintz; Christian J Bell; Kenya R Earl; Grant E Forsythe; Cécile Häberli; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

3.  Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.

Authors:  Lei You; Eun Jeong Cho; John Leavitt; Li-Chung Ma; Gaetano T Montelione; Eric V Anslyn; Robert M Krug; Andrew Ellington; Jon D Robertus
Journal:  Bioorg Med Chem Lett       Date:  2011-03-17       Impact factor: 2.823

4.  Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Authors:  Li Zhang; Beiying Qiu; Xin Li; Xin Wang; Jingya Li; Yongliang Zhang; Jian Liu; Jia Li; Jingkang Shen
Journal:  Molecules       Date:  2006-12-21       Impact factor: 4.411

5.  Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana.

Authors:  Karla Fabiola Chacón-Vargas; Sergio Andrade-Ochoa; Benjamín Nogueda-Torres; Dulce Carolina Juárez-Ramírez; Edgar E Lara-Ramírez; Ricardo Mondragón-Flores; Antonio Monge; Gildardo Rivera; Luvia Enid Sánchez-Torres
Journal:  Parasitol Res       Date:  2017-11-20       Impact factor: 2.289

6.  Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity.

Authors:  Xuemei Zhao; Chengcai Xia; Xiaodan Wang; Hao Wang; Ming Xin; Long Yu; Yulong Liang
Journal:  Front Pharmacol       Date:  2018-02-21       Impact factor: 5.810

7.  Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.

Authors:  Mohamed Alswah; Ashraf H Bayoumi; Kamal Elgamal; Ahmed Elmorsy; Saleh Ihmaid; Hany E A Ahmed
Journal:  Molecules       Date:  2017-12-27       Impact factor: 4.411

8.  Sensing study of quinoxaline analogues with theoretical calculation, single-crystal X-ray structure and real application in commercial fruit juices.

Authors:  Shampa Chakraborty; Shyamaprosad Goswami; Ching Kheng Quah; Bholanath Pakhira
Journal:  R Soc Open Sci       Date:  2018-06-06       Impact factor: 2.963

9.  Crystal structure and Hirshfeld surface analysis of ethyl 2-{4-[(3-methyl-2-oxo-1,2-di-hydro-quinoxalin-1-yl)meth-yl]-1H-1,2,3-triazol-1-yl}acetate.

Authors:  Nadeem Abad; Youssef Ramli; Tuncer Hökelek; Nada Kheira Sebbar; Joel T Mague; El Mokhtar Essassi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-10-23

10.  Silica bonded S-sulfonic acid: a recyclable catalyst for the synthesis of quinoxalines at room temperature.

Authors:  Khodabakhsh Niknam; Dariush Saberi; Maleki Mohagheghnejad
Journal:  Molecules       Date:  2009-05-22       Impact factor: 4.411
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