| Literature DB >> 16297626 |
Andrew Baxter1, Anne Cooper, Elizabeth Kinchin, Kerry Moakes, John Unitt, Alan Wallace.
Abstract
A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.Entities:
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Year: 2005 PMID： 16297626 DOI： 10.1016/j.bmcl.2005.10.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823