| Literature DB >> 16288280 |
Xiaojiang Gao1, Arman Bashirova, Astrid K N Iversen, John Phair, James J Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Marcus Altfeld, Stephen J O'Brien, Mary Carrington.
Abstract
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.Entities:
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Year: 2005 PMID： 16288280 DOI： 10.1038/nm1333
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440