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Literature DB >> 20505255

Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS.

Abstract

HIV-1 infection has rapidly spread worldwide and has become the leading cause of mortality in infectious diseases. The duration for development of AIDS (AIDS progression) is highly variable among HIV-1 infected individuals, ranging from 2-3 years to no signs of AIDS development in the entire lifetime. Several factors regulate the rate at which HIV-1 infection progresses to AIDS. Host genetic factors play an important role in the outcome of such complex or multifactor diseases as AIDS and are also known to regulate the rate of disease progression. This review focuses on the major host genes reported to affect the progression to AIDS in HIV-1 infected individuals.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 20505255 DOI： 10.1007/s12041-010-0003-4

Source DB: PubMed Journal: J Genet ISSN： 0022-1333 Impact factor: 1.166

103 in total

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Authors: Adam Jarmuz; Ann Chester; Jayne Bayliss; Jane Gisbourne; Ian Dunham; James Scott; Naveenan Navaratnam
Journal: Genomics Date: 2002-03 Impact factor: 5.736

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Journal: Nature Date: 1996-06-20 Impact factor: 49.962

4. Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort.

Authors: G Diop; T Hirtzig; H Do; C Coulonges; A Vasilescu; T Labib; J-L Spadoni; A Therwath; M Lathrop; F Matsuda; J-F Zagury
Journal: Biomed Pharmacother Date: 2006-08-31 Impact factor: 6.529

5. Global distribution of the CCR5 gene 32-basepair deletion.

Authors: J J Martinson; N H Chapman; D C Rees; Y T Liu; J B Clegg
Journal: Nat Genet Date: 1997-05 Impact factor: 38.330

Review 6. Considering genetic profiles in functional studies of immune responsiveness to HIV-1.

Authors: M Carrington; G Nelson; S J O'Brien
Journal: Immunol Lett Date: 2001-11-01 Impact factor: 3.685

Review 7. Cytokines in autoimmunity.

Authors: F M Brennan; M Feldmann
Journal: Curr Opin Immunol Date: 1996-12 Impact factor: 7.486

8. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

Authors: W A Paxton; S R Martin; D Tse; T R O'Brien; J Skurnick; N L VanDevanter; N Padian; J F Braun; D P Kotler; S M Wolinsky; R A Koup
Journal: Nat Med Date: 1996-04 Impact factor: 53.440

9. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.

Authors: M Dean; M Carrington; C Winkler; G A Huttley; M W Smith; R Allikmets; J J Goedert; S P Buchbinder; E Vittinghoff; E Gomperts; S Donfield; D Vlahov; R Kaslow; A Saah; C Rinaldo; R Detels; S J O'Brien
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10. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

Authors: A G Wilson; N de Vries; F Pociot; F S di Giovine; L B van der Putte; G W Duff
Journal: J Exp Med Date: 1993-02-01 Impact factor: 14.307

9 in total

Host genetic factors in susceptibility to HIV-1 infection and progression to AIDS.

1. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

2. Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2.

3. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

4. Exhaustive genotyping of the interferon alpha receptor 1 (IFNAR1) gene and association of an IFNAR1 protein variant with AIDS progression or susceptibility to HIV-1 infection in a French AIDS cohort.

5. Global distribution of the CCR5 gene 32-basepair deletion.

Review 6. Considering genetic profiles in functional studies of immune responsiveness to HIV-1.

Review 7. Cytokines in autoimmunity.

8. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

9. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.

10. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

Review 1. Unravelling the mechanisms of durable control of HIV-1.

2. MBL2 genetic polymorphisms and HIV-1 mother-to-child transmission in Zambia.

Review 3. Nanomedicine as an emerging approach against intracellular pathogens.

4. IL-18 Gene Promoter Region 607C/A Polymorphism in HIV-1 Infected North Indian Population.

5. Biomarkers of HIV Susceptibility and Disease Progression.

6. Polymorphisms in CCR5Δ32 and Risk of HIV-1 Infection in the Southeast of Caspian Sea, Iran.

7. Analysis of transporter associated with antigen presentation (TAP) genes polymorphisms with HIV-1 infection.

8. Long term non-progressor (LTNP) HIV infection.

Review 9. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.