| Literature DB >> 16279766 |
James T Anderson1, Anthony E Ting, Sherry Boozer, Kurt R Brunden, Chris Crumrine, Joel Danzig, Tom Dent, Laurel Faga, John J Harrington, William F Hodnick, Steven M Murphy, Gary Pawlowski, Robert Perry, Amy Raber, Stephen E Rundlett, Alain Stricker-Krongrad, Jianmin Wang, Youssef L Bennani.
Abstract
Analogues of the natural product noscapine were synthesized and their potential as antitumor agents evaluated. The discovery of a novel regioselective O-demethylation facilitated the synthesis of the potent aniline 6, which arrests mammalian cells in the G2/M phase of the cell cycle at 0.1 microM and also affects tubulin polymerization. Aniline 6 is orally bioavailable and is 250-fold more potent than noscapine in reducing cell proliferation in rapidly dividing cells.Entities:
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Year: 2005 PMID： 16279766 DOI： 10.1021/jm050674q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446