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Literature DB >> 16277348

Synthesis of double C-glycoside analogue of sTn.

Dino K Ress¹, Sultan N Baytas, Qun Wang, Eva M Muñoz, Kazuo Tokuzoki, Hiroshi Tomiyama, Robert J Linhardt.

Abstract

A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2005 PMID： 16277348 PMCID： PMC4112365 DOI： 10.1021/jo050691n

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

20 in total

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