Literature DB >> 16275918

X-ray absorption spectroscopy of chloroperoxidase compound I: Insight into the reactive intermediate of P450 chemistry.

Kari L Stone1, Rachel K Behan, Michael T Green.   

Abstract

We report the structural characterization of a thiolate-ligated ferryl radical. Using x-ray absorption spectroscopy, we examined chloroperoxidase (CPO) compound I (CPO-I). Our results indicate that CPO-I is an authentic ferryl species with an Fe-O bond of 1.65 A. Axial-ligand interactions result in a remarkably long 2.48-A Fe-S bond. Analogous forms of cytochrome P450 and CPO have been shown to possess virtually identical coordination environments. Thus, it seems likely that our findings provide a good structural description of the elusive P450-I.

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Year:  2005        PMID： 16275918      PMCID： PMC1283822          DOI： 10.1073/pnas.0507069102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

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Journal:  J Am Chem Soc       Date:  2004-03-31       Impact factor: 15.419

2.  Electronic structure of compound I in human isoforms of cytochrome P450 from QM/MM modeling.

Authors:  Christine M Bathelt; Jolanta Zurek; Adrian J Mulholland; Jeremy N Harvey
Journal:  J Am Chem Soc       Date:  2005-09-21       Impact factor: 15.419

3.  Probing structure-function relations in heme-containing oxygenases and peroxidases.

Authors:  J H Dawson
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4.  The P-450 nature of the carbon monoxide complex of ferrous chloroperoxidase.

Authors:  P F Hollenberg; L P Hager
Journal:  J Biol Chem       Date:  1973-04-10       Impact factor: 5.157

5.  Spectrum of chloroperoxidase compound I.

Authors:  M M Palcic; R Rutter; T Araiso; L P Hager; H B Dunford
Journal:  Biochem Biophys Res Commun       Date:  1980-06-30       Impact factor: 3.575

6.  Chloroperoxidase compound I: Electron paramagnetic resonance and Mössbauer studies.

Authors:  R Rutter; L P Hager; H Dhonau; M Hendrich; M Valentine; P Debrunner
Journal:  Biochemistry       Date:  1984-12-18       Impact factor: 3.162

7.  Kinetic characterization of compound I formation in the thermostable cytochrome P450 CYP119.

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8.  Oxoiron(IV) in chloroperoxidase compound II is basic: implications for P450 chemistry.

Authors:  Michael T Green; John H Dawson; Harry B Gray
Journal:  Science       Date:  2004-06-11       Impact factor: 47.728

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Authors:  Victor Guallar; Mu-Hyun Baik; Stephen J Lippard; Richard A Friesner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-27       Impact factor: 11.205

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Authors:  Cora E MacBeth; Rajeev Gupta; Katie R Mitchell-Koch; Victor G Young; Gerald H Lushington; Ward H Thompson; Michael P Hendrich; A S Borovik
Journal:  J Am Chem Soc       Date:  2004-03-03       Impact factor: 15.419
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  26 in total

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2.  Ferryl haem protonation gates peroxidatic reactivity in globins.

Authors:  Radu Silaghi-Dumitrescu; Brandon J Reeder; Peter Nicholls; Chris E Cooper; Michael T Wilson
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4.  Selective hydroxylation of alkanes by an extracellular fungal peroxygenase.

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5.  Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes.

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Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-26       Impact factor: 11.205

6.  Geometric and electronic structures of the His-Fe(IV)=O and His-Fe(IV)-Tyr hemes of MauG.

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Journal:  J Biol Inorg Chem       Date:  2012-09-30       Impact factor: 3.358

7.  A GGA+U approach to effective electronic correlations in thiolate-ligated iron-oxo (IV) porphyrin.

Authors:  Justin E Elenewski; John C Hackett
Journal:  J Chem Phys       Date:  2012-09-28       Impact factor: 3.488

8.  X-ray absorption near-edge spectroscopy in bioinorganic chemistry: Application to M-O2 systems.

Authors:  Ritimukta Sarangi
Journal:  Coord Chem Rev       Date:  2012-07-03       Impact factor: 22.315

9.  Spectra and kinetic studies of the compound I derivative of cytochrome P450 119.

Authors:  Xin Sheng; John H Horner; Martin Newcomb
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10.  Cytochrome P450 compound I in the plane wave pseudopotential framework: GGA electronic and geometric structure of thiolate-ligated iron(IV)-oxo porphyrin.

Authors:  Justin E Elenewski; John C Hackett
Journal:  J Comput Chem       Date:  2013-05-14       Impact factor: 3.376
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