Literature DB >> 16275081

Acryloylamino-salicylanilides as EGFR PTK inhibitors.

Wei Deng1, Zongru Guo, Yanshen Guo, Zhiqiang Feng, Yi Jiang, Fengming Chu.   

Abstract

A series of acryloylamino-salicylanilides were synthesized as inhibitors of EGFR PTK. A strategy of pseudo six-membered ring formed through intramolecular hydrogen bonding in salicylanilides is employed to mimic the planar pyrimidine ring of quinazoline EGFR inhibitors. Acrylamido moiety is incorporated to target the Cys-773 of EGFR specifically. Some of the obtained compounds exhibited good activity as EGFR inhibitors.

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Year:  2005        PMID： 16275081     DOI： 10.1016/j.bmcl.2005.06.088

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis.

Authors:  Wenjun Zhang; Megan L Bolla; Daniel Kahne; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2010-05-12       Impact factor: 15.419

2.  Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.

Authors:  Nada H El-Dershaby; Soad A El-Hawash; Shaymaa E Kassab; Hoda G Dabees; Ahmed E Abdel Moneim; Ibrahim A Abdel Wahab; Mohammad M Abd-Alhaseeb; Mostafa M M El-Miligy
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

3.  Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors.

Authors:  Alaaeldin M F Galal; Maha M Soltan; Esam R Ahmed; Atef G Hanna
Journal:  Medchemcomm       Date:  2018-07-26       Impact factor: 3.597

4.  Salicylanilide acetates: synthesis and antibacterial evaluation.

Authors:  Jarmila Vinsova; Ales Imramovsky; Vladimir Buchta; Martina Ceckova; Martin Dolezal; Frantisek Staud; Josef Jampilek; Jarmila Kaustova
Journal:  Molecules       Date:  2007-01-01       Impact factor: 4.411

5.  Antiproliferative and Pro-Apoptotic Effect of Novel Nitro-Substituted Hydroxynaphthanilides on Human Cancer Cell Lines.

Authors:  Tereza Kauerova; Jiri Kos; Tomas Gonec; Josef Jampilek; Peter Kollar
Journal:  Int J Mol Sci       Date:  2016-07-28       Impact factor: 5.923

6.  Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.

Authors:  Ales Imramovsky; Matus Pesko; Katarina Kralova; Marcela Vejsova; Jirina Stolarikova; Jarmila Vinsova; Josef Jampilek
Journal:  Molecules       Date:  2011-03-14       Impact factor: 4.411

7.  Investigating the spectrum of biological activity of ring-substituted salicylanilides and carbamoylphenylcarbamates.

Authors:  Jan Otevrel; Zuzana Mandelova; Matus Pesko; Jiahui Guo; Katarina Kralova; Frantisek Sersen; Marcela Vejsova; Danuta S Kalinowski; Zaklina Kovacevic; Aidan Coffey; Jozef Csollei; Des R Richardson; Josef Jampilek
Journal:  Molecules       Date:  2010-11-10       Impact factor: 4.411

8.  Optimization of substituted 6-salicyl-4-anilinoquinazoline derivatives as dual EGFR/HER2 tyrosine kinase inhibitors.

Authors:  Dong-Dong Li; Ya-Juan Qin; Jian Sun; Jing-Ran Li; Fei Fang; Qian-Ru Du; Yong Qian; Hai-Bin Gong; Hai-Liang Zhu
Journal:  PLoS One       Date:  2013-08-01       Impact factor: 3.240

9.  Antibacterial activity of salicylanilide 4-(trifluoromethyl)-benzoates.

Authors:  Martin Krátký; Jarmila Vinšová; Eva Novotná; Jana Mandíková; František Trejtnar; Jiřina Stolaková
Journal:  Molecules       Date:  2013-03-25       Impact factor: 4.411
  9 in total

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