Literature DB >> 16258246

The ribostamycin biosynthetic gene cluster in Streptomyces ribosidificus: comparison with butirosin biosynthesis.

Bimala Subba1, Madan Kumar Kharel, Hei Chan Lee, Kwangkyoung Liou, Byung-Gee Kim, Jae Kyung Sohng.   

Abstract

A cluster of genes for ribostamycin (Rbm) biosynthesis was isolated from Streptomyces ribosidificus ATCC 21294. Sequencing of 31.892 kb of the genomic DNA of S. ribosidificus revealed 26 open reading frames (ORFs) encoding putative Rbm biosynthetic genes as well as resistance and other genes. One of ten putative Rbm biosynthetic genes, rbmA, was expressed in S. lividans TK24, and shown to encode 2-deoxy-scyllo-inosose (DOI) synthase. Acetylation of various aminoglycoside-aminocyclitol (AmAcs) by RbmI confirmed it to be an aminoglycoside 3-N-acetyltransferase. Comparison of the genetic control of ribostamycin and butirosin biosynthesis pointed to a common biosynthetic route for these compounds, despite the considerable differences between them in genetic organization.

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Year:  2005        PMID： 16258246

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  9 in total

1.  Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

Authors:  Mamoru Komatsu; Kyoko Komatsu; Hanae Koiwai; Yuuki Yamada; Ikuko Kozone; Miho Izumikawa; Junko Hashimoto; Motoki Takagi; Satoshi Omura; Kazuo Shin-ya; David E Cane; Haruo Ikeda
Journal:  ACS Synth Biol       Date:  2013-01-17       Impact factor: 5.110

2.  Draft genome sequence of the marine sediment-derived actinomycete Streptomyces xinghaiensis NRRL B24674T.

Authors:  Xinqing Zhao; Tianhong Yang
Journal:  J Bacteriol       Date:  2011-10       Impact factor: 3.490

Review 3.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

4.  Functional and kinetic analysis of the phosphotransferase CapP conferring selective self-resistance to capuramycin antibiotics.

Authors:  Zhaoyong Yang; Masanori Funabashi; Koichi Nonaka; Masahiko Hosobuchi; Tomoyuki Shibata; Pallab Pahari; Steven G Van Lanen
Journal:  J Biol Chem       Date:  2010-03-04       Impact factor: 5.157

5.  Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae.

Authors:  Guanying Shi; Xingang Zhang; Lang Wu; Jin Xie; Ke Tao; Taiping Hou
Journal:  Folia Microbiol (Praha)       Date:  2011-11-15       Impact factor: 2.099

6.  The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin.

Authors:  Trevor R Zachman-Brockmeyer; James B Thoden; Hazel M Holden
Journal:  Protein Sci       Date:  2017-07-23       Impact factor: 6.725

7.  Delineating the biosynthesis of gentamicin x2, the common precursor of the gentamicin C antibiotic complex.

Authors:  Chuan Huang; Fanglu Huang; Eileen Moison; Junhong Guo; Xinyun Jian; Xiaobo Duan; Zixin Deng; Peter F Leadlay; Yuhui Sun
Journal:  Chem Biol       Date:  2015-01-29

8.  Homology modeling and assigned functional annotation of an uncharacterized antitoxin protein from Streptomyces xinghaiensis.

Authors:  Arafat Rahman Oany; Md Shahabuddin Ahmed; Nasreen Jahan; Md Abdul Latif; Shahin Mahmud; Md Ahmed Hossain; Fatema Akter; Hasibul Haque Rakib; Md Shariful Islam
Journal:  Bioinformation       Date:  2015-11-30

9.  Specificity and promiscuity at the branch point in gentamicin biosynthesis.

Authors:  Junhong Guo; Fanglu Huang; Chuan Huang; Xiaobo Duan; Xinyun Jian; Finian Leeper; Zixin Deng; Peter F Leadlay; Yuhui Sun
Journal:  Chem Biol       Date:  2014-04-17
  9 in total

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