Literature DB >> 1625494

Selective toxicity of ethacrynic acid towards lymphocytes of chronic lymphocytic leukemia in vitro.

P R Twentyman1, E Lambert, M Müller, J K Rees.   

Abstract

We have used the MTT colorimetric assay to determine the sensitivity to ethacrynic acid of lymphocytes from normal donors and of peripheral blood cells from leukaemia patients. Whereas normal lymphocytes and cells from acute or chronic myeloid leukaemia showed similar sensitivities (median inhibitory dose, ID50 = 20-22 microM), lymphocytes from chronic lymphocytic leukaemia patients were much more sensitive (ID50 = 6 microM). This result was found irrespective of the assay duration.

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Year:  1992        PMID： 1625494

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  6 in total

1.  Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.

Authors:  Zack E Bryant; Romy F J Janser; Medina Jabarkhail; Melissa S Candelaria-Lyons; Brittni B Romero; Severine Van slambrouck; Wim F A Steelant; Ingo Janser
Journal:  Bioorg Med Chem Lett       Date:  2010-12-19       Impact factor: 2.823

2.  Ethacrynic acid analogues lacking the alpha,beta-unsaturated carbonyl unit--potential anti-metastatic drugs.

Authors:  Romy F J Janser; Ranjith K Meka; Zack E Bryant; Enoch A Adogla; Elizabeth K Vogel; Jaimie L Wharton; Cynthia M Tilley; Catherine N Kaminski; Seth L Ferrey; Severine Van Slambrouck; Wim F A Steelant; Ingo Janser
Journal:  Bioorg Med Chem Lett       Date:  2010-02-02       Impact factor: 2.823

3.  Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival.

Authors:  Guangyi Jin; Desheng Lu; Shiyin Yao; Christina C N Wu; Jerry X Liu; Dennis A Carson; Howard B Cottam
Journal:  Bioorg Med Chem Lett       Date:  2008-12-24       Impact factor: 2.823

Review 4.  Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.

Authors:  Larion Santiago; Garrett Daniels; Dongwen Wang; Fang-Ming Deng; Peng Lee
Journal:  Am J Cancer Res       Date:  2017-06-01       Impact factor: 6.166

5.  Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

Authors:  Desheng Lu; Jerry X Liu; Tomoyuki Endo; Haowen Zhou; Shiyin Yao; Karl Willert; Ingo G H Schmidt-Wolf; Thomas J Kipps; Dennis A Carson
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240

6.  High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid.

Authors:  Wei Wu; Huayuan Zhu; Yuan Fu; Wenyi Shen; Kourong Miao; Min Hong; Wei Xu; Lei Fan; Ken H Young; Peng Liu; Jianyong Li
Journal:  Oncotarget       Date:  2016-04-19
  6 in total

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