| Literature DB >> 20172724 |
Romy F J Janser1, Ranjith K Meka, Zack E Bryant, Enoch A Adogla, Elizabeth K Vogel, Jaimie L Wharton, Cynthia M Tilley, Catherine N Kaminski, Seth L Ferrey, Severine Van Slambrouck, Wim F A Steelant, Ingo Janser.
Abstract
A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20172724 PMCID： PMC2839078 DOI： 10.1016/j.bmcl.2010.01.144
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823