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Literature DB >> 22908150

Antibiotic resistance and substrate profiles of the class A carbapenemase KPC-6.

Toni L Lamoureaux¹, Hilary Frase, Nuno T Antunes, Sergei B Vakulenko.

Abstract

The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(-1) s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater extent, ranging from 10(3) M(-1) s(-1) for the cephamycin cefoxitin and the extended-spectrum cephalosporin ceftazidime to 10(5) to 10(6) M(-1) s(-1) for the narrow-spectrum and some of the extended-spectrum cephalosporins.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22908150 PMCID： PMC3486543 DOI： 10.1128/AAC.01338-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. The determination of enzyme inhibitor constants.

Authors: M DIXON
Journal: Biochem J Date: 1953-08 Impact factor: 3.857

2. Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.

Authors: Jimena Alba; Yoshikazu Ishii; Kenneth Thomson; Ellen Smith Moland; Keizo Yamaguchi
Journal: Antimicrob Agents Chemother Date: 2005-11 Impact factor: 5.191

3. The release of enzymes from Escherichia coli by osmotic shock and during the formation of spheroplasts.

Authors: H C Neu; L A Heppel
Journal: J Biol Chem Date: 1965-09 Impact factor: 5.157

4. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.

Authors: H Yigit; A M Queenan; G J Anderson; A Domenech-Sanchez; J W Biddle; C D Steward; S Alberti; K Bush; F C Tenover
Journal: Antimicrob Agents Chemother Date: 2001-04 Impact factor: 5.191

5. Class A carbapenemase FPH-1 from Francisella philomiragia.

Authors: Marta Toth; Viktoria Vakulenko; Nuno T Antunes; Hilary Frase; Sergei B Vakulenko
Journal: Antimicrob Agents Chemother Date: 2012-03-26 Impact factor: 5.191

6. Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

Authors: Delphine Girlich; Laurent Poirel; Patrice Nordmann
Journal: Antimicrob Agents Chemother Date: 2009-11-09 Impact factor: 5.191

Review 7. Class A carbapenemases.

Authors: Jan Walther-Rasmussen; Niels Høiby
Journal: J Antimicrob Chemother Date: 2007-06-26 Impact factor: 5.790

8. Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases.

Authors: Hilary Frase; Qicun Shi; Sebastian A Testero; Shahriar Mobashery; Sergei B Vakulenko
Journal: J Biol Chem Date: 2009-08-05 Impact factor: 5.157

Review 9. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.

Authors: Patrice Nordmann; Gaelle Cuzon; Thierry Naas
Journal: Lancet Infect Dis Date: 2009-04 Impact factor: 25.071

10. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4.

Authors: Daniel J Wolter; Philip M Kurpiel; Neil Woodford; Marie-France I Palepou; Richard V Goering; Nancy D Hanson
Journal: Antimicrob Agents Chemother Date: 2008-11-17 Impact factor: 5.191

8 in total

1. Community-Acquired Pyelonephritis in Pregnancy Caused by KPC-Producing Klebsiella pneumoniae.

Authors: Asma Khatri; Nina Naeger Murphy; Peter Wiest; Melissa Osborn; Kathleen Garber; Michelle Hecker; Kelly Hurless; Susan D Rudin; Michael R Jacobs; Robert C Kalayjian; Robert A Salata; David van Duin; Federico Perez; Robert A Bonomo; David L Paterson; Patrick N A Harris
Journal: Antimicrob Agents Chemother Date: 2015-08 Impact factor: 5.191

2. TEM,CTX-M,SHV Genes in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a County Clinical Emergency Hospital Romania-Predominance of CTX-M-15.

Authors: Alice Elena Ghenea; Ovidiu Mircea Zlatian; Oana Mariana Cristea; Anca Ungureanu; Radu Razvan Mititelu; Andrei Theodor Balasoiu; Corina Maria Vasile; Alex-Ioan Salan; Daniel Iliuta; Mihaela Popescu; Anca-Loredana Udriștoiu; Maria Balasoiu
Journal: Antibiotics (Basel) Date: 2022-04-10

3. A novel extended-spectrum β-lactamase, SGM-1, from an environmental isolate of Sphingobium sp.

Authors: Toni L Lamoureaux; Viktoria Vakulenko; Marta Toth; Hilary Frase; Sergei B Vakulenko
Journal: Antimicrob Agents Chemother Date: 2013-05-28 Impact factor: 5.191

4. C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.

Authors: Nichole K Stewart; Marta Toth; Maha A Alqurafi; Weirui Chai; Thu Q Nguyen; Pojun Quan; Mijoon Lee; John D Buynak; Clyde A Smith; Sergei B Vakulenko
Journal: mBio Date: 2022-04-14 Impact factor: 7.786

5. Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability.

Authors: Shrenik C Mehta; Kacie Rice; Timothy Palzkill
Journal: PLoS Pathog Date: 2015-06-01 Impact factor: 6.823