| Literature DB >> 16246554 |
Sachiko Tsukamoto1, Takushi Yoshida, Hidetaka Hosono, Tomihisa Ohta, Hideyoshi Yokosawa.
Abstract
A new inhibitor of p53-HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (-)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53-HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC(50) value of 50 microg/mL. Although a number of synthetic inhibitors of p53-HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources.Entities:
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Year: 2005 PMID： 16246554 DOI： 10.1016/j.bmcl.2005.09.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823