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Literature DB >> 22104152

Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction.

Karla L Malloy¹, Hyukjae Choi, Catherine Fiorilla, Fred A Valeriote, Teatulohi Matainaho, William H Gerwick.

Abstract

Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yielded hoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine residue. Hoiamide D displayed inhibitory activity against p53/MDM2 interaction (EC(50)=4.5 μM), an attractive target for anticancer drug development.

Entities: CellLine Chemical Disease Gene Species

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Year: 2011 PMID： 22104152 PMCID： PMC3248991 DOI： 10.1016/j.bmcl.2011.10.054

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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