BACKGROUND: Although cigarette smoking is considered a major risk factor for bladder carcinoma, little is known about the interaction between metabolic genes such as glutathione-S-transferase P1 and tobacco smoking in this process. GSTP1 may play a role in detoxification of tobacco-related carcinogens. METHODS: In this case-control study of 145 cases with bladder carcinoma (male:female = 7.5:1) and 170 noncancer controls (male:female = 3.7:1), the relation between genetic polymorphisms of GSTP1 and susceptibility to bladder carcinoma was investigated and the gene-environment interaction between tobacco smoking and GSTP1 polymorphism was evaluated. Epidemiological data were collected for all cases and controls by a standard questionnaire. Polymorphisms of GSTP1 were measured by polymerase chain reaction-restriction fragment length polymorphism. The logistic regression model in SAS was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Cigarette smoking was confirmed as a risk factor of bladder carcinoma with an OR of 3.1 (95% CI: 1.7-5.9) after controlling for potential confounding factors. The OR for pack-years of smoking as a continuous variable was 2.4 (95% CI: 2.0-2.8). The ORs were 7.6 (95% CI: 1.18-49.51) for isoleucine/valine (Ile/Val) and 6.5 (95% CI: 1.01-41.56) for Ile/Ile when the homozygous Val/Val was considered as comparison group after adjusting for age, gender, race, and education. The adjusted OR for interaction between smoking and the GSTP1 (any Ile genotype) was 11.42 (95% CI: 0.53-248.15). CONCLUSIONS: The results indicate that the Ile 105 allele is associated with an increased risk of bladder carcinoma and suggest that individuals who smoke and possess the Ile allele might be at increased risk for bladder carcinoma.
BACKGROUND: Although cigarette smoking is considered a major risk factor for bladder carcinoma, little is known about the interaction between metabolic genes such as glutathione-S-transferase P1 and tobacco smoking in this process. GSTP1 may play a role in detoxification of tobacco-related carcinogens. METHODS: In this case-control study of 145 cases with bladder carcinoma (male:female = 7.5:1) and 170 noncancer controls (male:female = 3.7:1), the relation between genetic polymorphisms of GSTP1 and susceptibility to bladder carcinoma was investigated and the gene-environment interaction between tobacco smoking and GSTP1 polymorphism was evaluated. Epidemiological data were collected for all cases and controls by a standard questionnaire. Polymorphisms of GSTP1 were measured by polymerase chain reaction-restriction fragment length polymorphism. The logistic regression model in SAS was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Cigarette smoking was confirmed as a risk factor of bladder carcinoma with an OR of 3.1 (95% CI: 1.7-5.9) after controlling for potential confounding factors. The OR for pack-years of smoking as a continuous variable was 2.4 (95% CI: 2.0-2.8). The ORs were 7.6 (95% CI: 1.18-49.51) for isoleucine/valine (Ile/Val) and 6.5 (95% CI: 1.01-41.56) for Ile/Ile when the homozygous Val/Val was considered as comparison group after adjusting for age, gender, race, and education. The adjusted OR for interaction between smoking and the GSTP1 (any Ile genotype) was 11.42 (95% CI: 0.53-248.15). CONCLUSIONS: The results indicate that the Ile 105 allele is associated with an increased risk of bladder carcinoma and suggest that individuals who smoke and possess the Ile allele might be at increased risk for bladder carcinoma.
Authors: Sungshim L Park; Delara Bastani; Binh Y Goldstein; Shen-Chih Chang; Wendy Cozen; Lin Cai; Carlos Cordon-Cardo; Baoguo Ding; Sander Greenland; Na He; Shehnaz K Hussain; Qingwu Jiang; Yuan-Chin A Lee; Simin Liu; Ming-Lan Lu; Thomas M Mack; Jenny T Mao; Hal Morgenstern; Li-Na Mu; Sam S Oh; Allan Pantuck; Jeanette C Papp; Jianyu Rao; Victor E Reuter; Donald P Tashkin; Hua Wang; Nai-Chieh Y You; Shun-Zhang Yu; Jin-Kou Zhao; Zuo-Feng Zhang Journal: Carcinogenesis Date: 2010-05-17 Impact factor: 4.944
Authors: Sam S Oh; Shen-Chih Chang; Lin Cai; Carlos Cordon-Cardo; Bao-Guo Ding; Sander Greenland; Na He; Qingwu Jiang; Leeka Kheifets; Anh Le; Yuan-Chin Amy Lee; Simin Liu; Ming-Lan Lu; Jenny T Mao; Hal Morgenstern; Li-Na Mu; Allan Pantuck; Jeanette C Papp; Sungshim Lani Park; Jian Yu Rao; Victor E Reuter; Donald P Tashkin; Hua Wang; Nai-Chieh Y You; Shun-Zhang Yu; Jin-Kou Zhao; Arie Belldegrun; Zuo-Feng Zhang Journal: Int J Cancer Date: 2010-11-01 Impact factor: 7.396
Authors: Daniel J Conklin; Petra Haberzettl; Russell A Prough; Aruni Bhatnagar Journal: Am J Physiol Heart Circ Physiol Date: 2009-03-06 Impact factor: 4.733
Authors: Mariana C Stern; Jie Lin; Jonine D Figueroa; Karl T Kelsey; Anne E Kiltie; Jian-Min Yuan; Giuseppe Matullo; Tony Fletcher; Simone Benhamou; Jack A Taylor; Donatella Placidi; Zuo-Feng Zhang; Gunnar Steineck; Nathaniel Rothman; Manolis Kogevinas; Debra Silverman; Nuria Malats; Stephen Chanock; Xifeng Wu; Margaret R Karagas; Angeline S Andrew; Heather H Nelson; D Timothy Bishop; Sei Chung Sak; Ananya Choudhury; Jennifer H Barrett; Faye Elliot; Román Corral; Amit D Joshi; Manuela Gago-Dominguez; Victoria K Cortessis; Yong-Bing Xiang; Yu-Tang Gao; Paolo Vineis; Carlotta Sacerdote; Simonetta Guarrera; Silvia Polidoro; Alessandra Allione; Eugen Gurzau; Kvetoslava Koppova; Rajiv Kumar; Peter Rudnai; Stefano Porru; Angela Carta; Marcello Campagna; Cecilia Arici; Sung Shim Lani Park; Montserrat Garcia-Closas Journal: Cancer Res Date: 2009-08-25 Impact factor: 12.701
Authors: Tatjana Simic; Ana Savic-Radojevic; Marija Pljesa-Ercegovac; Marija Matic; Jasmina Mimic-Oka Journal: Nat Rev Urol Date: 2009-05 Impact factor: 14.432