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Literature DB >> 16227506

Extending a spectrin repeat unit. I: linear force-extension response.

Sterling Paramore¹, Gary S Ayton, Dina T Mirijanian, Gregory A Voth.

Abstract

Nonequilibrium molecular dynamics simulations were used to calculate the elastic properties of a spectrin repeat unit. A contiguous alpha-helical linker was constructed by employing periodic boundary conditions, allowing a novel scheme for evaluating the thermodynamic force as a function of extension. By measuring the force-extension response under small extensions, spectrin was observed to behave primarily as an elastic material with a spring constant of 1700 +/- 100 pN/nm. The implications of this spring constant, in terms of the properties of the spectrin tetramer, are also discussed.

Mesh：

Substances：
Water
Spectrin
Carbon

Year: 2005 PMID： 16227506 PMCID： PMC1367040 DOI： 10.1529/biophysj.105.066969

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

45 in total

1. Calculating the bulk modulus for a lipid bilayer with nonequilibrium molecular dynamics simulation.

Authors: Gary Ayton; Alexander M Smondyrev; Scott G Bardenhagen; Patrick McMurtry; Gregory A Voth
Journal: Biophys J Date: 2002-03 Impact factor: 4.033

2. Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains.

Authors: Richard Law; George Liao; Sandy Harper; Guoliang Yang; David W Speicher; Dennis E Discher
Journal: Biophys J Date: 2003-11 Impact factor: 4.033

3. Structural insights into the stability and flexibility of unusual erythroid spectrin repeats.

Authors: Hideki Kusunoki; Ruby I MacDonald; Alfonso Mondragón
Journal: Structure Date: 2004-04 Impact factor: 5.006

4. Thermoelasticity of red blood cell membrane.

Authors: R Waugh; E A Evans
Journal: Biophys J Date: 1979-04 Impact factor: 4.033

5. The molecular basis of erythrocyte shape.

Authors: A Elgsaeter; B T Stokke; A Mikkelsen; D Branton
Journal: Science Date: 1986-12-05 Impact factor: 47.728

6. Location of the human red cell spectrin tetramer binding site and detection of a related "closed" hairpin loop dimer using proteolytic footprinting.

Authors: D W Speicher; T M DeSilva; K D Speicher; J A Ursitti; P Hembach; L Weglarz
Journal: J Biol Chem Date: 1993-02-25 Impact factor: 5.157

7. Crystal structure of the repetitive segments of spectrin.

Authors: Y Yan; E Winograd; A Viel; T Cronin; S C Harrison; D Branton
Journal: Science Date: 1993-12-24 Impact factor: 47.728

8. Erythrocyte spectrin is comprised of many homologous triple helical segments.

Authors: D W Speicher; V T Marchesi
Journal: Nature Date: 1984 Sep 13-19 Impact factor: 49.962

9. The molecular structure of human erythrocyte spectrin. Biophysical and electron microscopic studies.

Authors: D M Shotton; B E Burke; D Branton
Journal: J Mol Biol Date: 1979-06-25 Impact factor: 5.469

10. The key event in force-induced unfolding of Titin's immunoglobulin domains.

Authors: H Lu; K Schulten
Journal: Biophys J Date: 2000-07 Impact factor: 4.033

12 in total

1. Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes.

Authors: Gayani C Kodippili; Jeff Spector; Jacob Hale; Katie Giger; Michael R Hughes; Kelly M McNagny; Connie Birkenmeier; Luanne Peters; Ken Ritchie; Philip S Low
Journal: J Biol Chem Date: 2011-12-06 Impact factor: 5.157

2. Extending a spectrin repeat unit. II: rupture behavior.

Authors: Sterling Paramore; Gary S Ayton; Gregory A Voth
Journal: Biophys J Date: 2005-10-14 Impact factor: 4.033

3. Examining the influence of linkers and tertiary structure in the forced unfolding of multiple-repeat spectrin molecules.

Authors: Sterling Paramore; Gregory A Voth
Journal: Biophys J Date: 2006-08-04 Impact factor: 4.033

Extending a spectrin repeat unit. I: linear force-extension response.

1. Calculating the bulk modulus for a lipid bilayer with nonequilibrium molecular dynamics simulation.

2. Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains.

3. Structural insights into the stability and flexibility of unusual erythroid spectrin repeats.

4. Thermoelasticity of red blood cell membrane.

5. The molecular basis of erythrocyte shape.

6. Location of the human red cell spectrin tetramer binding site and detection of a related "closed" hairpin loop dimer using proteolytic footprinting.

7. Crystal structure of the repetitive segments of spectrin.

8. Erythrocyte spectrin is comprised of many homologous triple helical segments.

9. The molecular structure of human erythrocyte spectrin. Biophysical and electron microscopic studies.

10. The key event in force-induced unfolding of Titin's immunoglobulin domains.

1. Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes.

2. Extending a spectrin repeat unit. II: rupture behavior.

3. Examining the influence of linkers and tertiary structure in the forced unfolding of multiple-repeat spectrin molecules.

4. Spectrin domains lose cooperativity in forced unfolding.

Review 5. Finding the weakest link: exploring integrin-mediated mechanical molecular pathways.

6. DARC, Glycophorin A, Band 3, and GLUT1 Diffusion in Erythrocytes: Insights into Membrane Complexes.

7. Mechanical Unfolding of Spectrin Repeats Induces Water-Molecule Ordering.

8. Elasticity and rupture of a multi-domain neural cell adhesion molecule complex.

Review 9. Cytoskeletal control of axon domain assembly and function.

10. Imaging of the diffusion of single band 3 molecules on normal and mutant erythrocytes.