PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
PURPOSE: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS). DESIGN: Test-retest reproducibility study. METHODS: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream. RESULTS: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%. CONCLUSIONS: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.
Authors: Neil O'Leary; David P Crabb; Steven L Mansberger; Brad Fortune; Michael D Twa; Michael J Lloyd; Aachal Kotecha; David F Garway-Heath; George A Cioffi; Chris A Johnson Journal: Arch Ophthalmol Date: 2010-05
Authors: Vatinee Y Bunya; David H Brainard; Ebenezer Daniel; Mina Massaro-Giordano; William Nyberg; Elizabeth A Windsor; Denise J Pearson; Jiayan Huang; Maureen G Maguire; Richard A Stone Journal: Cornea Date: 2013-11 Impact factor: 2.651
Authors: Lindsey S Folio; Gadi Wollstein; Jacek Kotowski; Richard A Bilonick; Yun Ling; Hiroshi Ishikawa; Larry Kagemann; Joel S Schuman Journal: Br J Ophthalmol Date: 2012-11-30 Impact factor: 4.638
Authors: Henry D Jampel; David Friedman; Harry Quigley; Susan Vitale; Rhonda Miller; Frederick Knezevich; Yulan Ding Journal: Am J Ophthalmol Date: 2008-09-13 Impact factor: 5.258
Authors: Felipe A Medeiros; Luciana M Alencar; Linda M Zangwill; Christopher Bowd; Pamela A Sample; Robert N Weinreb Journal: Arch Ophthalmol Date: 2009-10
Authors: Felipe A Medeiros; Linda M Zangwill; Luciana M Alencar; Christopher Bowd; Pamela A Sample; Remo Susanna; Robert N Weinreb Journal: Invest Ophthalmol Vis Sci Date: 2009-10-08 Impact factor: 4.799