Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A new approach to understand the pathophysiology of Parkinson's disease.

Literature DB >> 16222431

A new approach to understand the pathophysiology of Parkinson's disease.

Abstract

Here I introduce a dynamic model of the basal ganglia functions for the control of voluntary movement: information through major pathways in the cortico-basal ganglia loop, i. e., the cortico-STN-GPi/SNr "hyperdirect", cortico-striato-GPi/SNr "direct" and cortico-striato-GPe-STN-GPi/SNr "indirect" pathways, dynamically controls the activity of the thalamus and cortex and releases only the selected motor program at the selected timing. Based on the dynamic model, the pathophysiology of Parkinson's disease and the mechanism for the effectiveness of stereotaxic surgery can better be explained by an increase or decrease of disinhibition and inhibition in the thalamus and cortex in the temporal and spatial domains.

Entities: Disease Gene

Mesh：

Year: 2005 PMID： 16222431 DOI： 10.1007/s00415-005-4002-y

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

18 in total

1. Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey.

Authors: A Nambu; H Tokuno; I Hamada; H Kita; M Imanishi; T Akazawa; Y Ikeuchi; N Hasegawa
Journal: J Neurophysiol Date: 2000-07 Impact factor: 2.714

Review 2. Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway.

Authors: Atsushi Nambu; Hironobu Tokuno; Masahiko Takada
Journal: Neurosci Res Date: 2002-06 Impact factor: 3.304

3. Convergence of subthalamic and striatal efferents at pallidal level in primates: an anterograde double-labeling study with biocytin and PHA-L.

Authors: L N Hazrati; A Parent
Journal: Brain Res Date: 1992-01-13 Impact factor: 3.252

4. The impact of deep brain stimulation on executive function in Parkinson's disease.

Authors: M Jahanshahi; C M Ardouin; R G Brown; J C Rothwell; J Obeso; A Albanese; M C Rodriguez-Oroz; E Moro; A L Benabid; P Pollak; P Limousin-Dowsey
Journal: Brain Date: 2000-06 Impact factor: 13.501

5. Dual somatotopical representations in the primate subthalamic nucleus: evidence for ordered but reversed body-map transformations from the primary motor cortex and the supplementary motor area.

Authors: A Nambu; M Takada; M Inase; H Tokuno
Journal: J Neurosci Date: 1996-04-15 Impact factor: 6.167

Review 6. The functional anatomy of basal ganglia disorders.

Authors: R L Albin; A B Young; J B Penney
Journal: Trends Neurosci Date: 1989-10 Impact factor: 13.837

7. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus.

Authors: H Bergman; T Wichmann; M R DeLong
Journal: Science Date: 1990-09-21 Impact factor: 47.728

Review 8. Basal ganglia intrinsic circuits and their role in behavior.

Authors: J W Mink; W T Thach
Journal: Curr Opin Neurobiol Date: 1993-12 Impact factor: 6.627

9. Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey.

Authors: K H Monakow; K Akert; H Künzle
Journal: Exp Brain Res Date: 1978-11-15 Impact factor: 1.972

Review 10. Deep brain stimulation for Parkinson's disease: disrupting the disruption.

Authors: Andres M Lozano; Jonathan Dostrovsky; Robert Chen; Peter Ashby
Journal: Lancet Neurol Date: 2002-08 Impact factor: 44.182

24 in total

1. Changing views of basal ganglia circuits and circuit disorders.

Authors: Mahlon DeLong; Thomas Wichmann
Journal: Clin EEG Neurosci Date: 2010-04 Impact factor: 1.843

2. Neuronal Entropy-Rate Feature of Entopeduncular Nucleus in Rat Model of Parkinson's Disease.

Authors: Olivier Darbin; Xingxing Jin; Christof Von Wrangel; Kerstin Schwabe; Atsushi Nambu; Dean K Naritoku; Joachim K Krauss; Mesbah Alam
Journal: Int J Neural Syst Date: 2015-10-06 Impact factor: 5.866

Review 3. Anatomy, Physiology, and Clinical Syndromes of the Basal Ganglia: A Brief Review.

Authors: Arash Fazl; Jori Fleisher
Journal: Semin Pediatr Neurol Date: 2017-12-27 Impact factor: 1.636

4. Identification and comparison of stochastic metabolic/hemodynamic models (sMHM) for the generation of the BOLD signal.

Authors: Roberto C Sotero; Nelson J Trujillo-Barreto; Juan C Jiménez; Felix Carbonell; Rafael Rodríguez-Rojas
Journal: J Comput Neurosci Date: 2008-10-03 Impact factor: 1.621

5. Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.

Authors: Chun-Hwei Tai; Ya-Chin Yang; Ming-Kai Pan; Chen-Syuan Huang; Chung-Chin Kuo
Journal: J Clin Invest Date: 2011-08 Impact factor: 14.808

6. Functional neuroanatomy of the basal ganglia.

Authors: José L Lanciego; Natasha Luquin; José A Obeso
Journal: Cold Spring Harb Perspect Med Date: 2012-12-01 Impact factor: 6.915

7. NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate.

Authors: Subhrajit Bhattacharya; Yuxian Ma; Amy R Dunn; Joshua M Bradner; Annalisa Scimemi; Gary W Miller; Stephen F Traynelis; Thomas Wichmann
Journal: J Neurosci Res Date: 2018-03-25 Impact factor: 4.164

8. Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production.

Authors: Witold J Lipski; Ahmad Alhourani; Tara Pirnia; Peter W Jones; Christina Dastolfo-Hromack; Leah B Helou; Donald J Crammond; Susan Shaiman; Michael W Dickey; Lori L Holt; Robert S Turner; Julie A Fiez; R Mark Richardson
Journal: J Neurosci Date: 2018-05-22 Impact factor: 6.167

Review 9. Diagnosis and treatment of common forms of tremor.

Authors: Andreas Puschmann; Zbigniew K Wszolek
Journal: Semin Neurol Date: 2011-02-14 Impact factor: 3.420

Review 10. The T-type calcium channel as a new therapeutic target for Parkinson's disease.

Authors: Ya-Chin Yang; Chun-Hwei Tai; Ming-Kai Pan; Chung-Chin Kuo
Journal: Pflugers Arch Date: 2014-02-18 Impact factor: 3.657