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Literature DB >> 16213831

Critically short telomeres are associated with sperm DNA fragmentation.

Silvia Rodríguez¹, Vicente Goyanes, Enrique Segrelles, María Blasco, Jaime Gosálvez, José Luis Fernández.

Abstract

The influence of critical telomeric attrition, a well-known trigger of apoptosis and cell arrest, on sperm DNA fragmentation was studied in late-generation knockout mice for Terc, the RNA component of telomerase, as a model of choice. Terc knockout mice had a sixfold mean increase in the percentage of sperm cells with fragmented DNA.

Entities: Gene Species

Mesh：

Year: 2005 PMID： 16213831 DOI： 10.1016/j.fertnstert.2005.05.014

Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329

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Cited

11 in total

1. Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICSI of fertile oocyte donors?

Authors: Jaime Gosálvez; Pedro Caballero; Carmen López-Fernández; Leonor Ortega; José Andrés Guijarro; José Luís Fernández; Stephen D Johnston; Rocío Nuñez-Calonge
Journal: Asian J Androl Date: 2013-10-14 Impact factor: 3.285

2. Telomere lengths in human oocytes, cleavage stage embryos and blastocysts.

Authors: S Turner; H P Wong; J Rai; G M Hartshorne
Journal: Mol Hum Reprod Date: 2010-06-23 Impact factor: 4.025

3. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays.

Authors: Yves Menezo; GianLuigi Russo; Elisabetta Tosti; Said El Mouatassim; Moncef Benkhalifa
Journal: J Assist Reprod Genet Date: 2007-09-27 Impact factor: 3.412

Critically short telomeres are associated with sperm DNA fragmentation.

1. Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICSI of fertile oocyte donors?

2. Telomere lengths in human oocytes, cleavage stage embryos and blastocysts.

3. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays.

4. Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss.

5. DNA fragmentation in microorganisms assessed in situ.

Review 6. Sperm DNA and detection of DNA fragmentations in sperm.

Review 7. Telomere homeostasis in mammalian germ cells: a review.

Review 8. Male Factors: the Role of Sperm in Preimplantation Embryo Quality.

9. Reduced sperm telomere length in individuals with varicocele is associated with reduced genomic integrity.

Review 10. Novel insights into the genetic and epigenetic paternal contribution to the human embryo.