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Literature DB >> 16192755

Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.

Seokjoon Lee¹, Sangtae Oh, Gab-Man Park, Tong-Soo Kim, Jae-Sook Ryu, Han-Kyu Choi.

Abstract

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Entities: Chemical Species

Mesh：

Substances：

Year: 2005 PMID： 16192755 PMCID： PMC2712013 DOI： 10.3347/kjp.2005.43.3.123

Source DB: PubMed Journal: Korean J Parasitol ISSN： 0023-4001 Impact factor: 1.341

18 in total

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Authors: J A Vroman; M Alvim-Gaston; M A Avery
Journal: Curr Pharm Des Date: 1999-02 Impact factor: 3.116

2. Antitumor activity of novel deoxoartemisinin monomers, dimers, and trimer.

Authors: Mankil Jung; Sangmin Lee; Jungyeob Ham; Kyunghoon Lee; Hanjo Kim; Soo Kie Kim
Journal: J Med Chem Date: 2003-03-13 Impact factor: 7.446

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Authors: M Jung; S Lee
Journal: Bioorg Med Chem Lett Date: 1998-05-05 Impact factor: 2.823

4. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

Authors: Gary H Posner; Ik-Hyeon Paik; Surojit Sur; Andrew J McRiner; Kristina Borstnik; Suji Xie; Theresa A Shapiro
Journal: J Med Chem Date: 2003-03-13 Impact factor: 7.446

5. Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity.

Authors: Laurence Delhaes; Christophe Biot; Laurence Berry; Philippe Delcourt; Lucien A Maciejewski; Daniel Camus; Jacques S Brocard; Daniel Dive
Journal: Chembiochem Date: 2002-05-03 Impact factor: 3.164

6. Antimalarial sulfide, sulfone, and sulfonamide trioxanes.

Authors: G H Posner; J P Maxwell; H O'Dowd; M Krasavin; S Xie; T A Shapiro
Journal: Bioorg Med Chem Date: 2000-06 Impact factor: 3.641

7. Plasmodium falciparum in culture: establishment of additional strains.

Authors: J B Jensen; W Trager
Journal: Am J Trop Med Hyg Date: 1978-07 Impact factor: 2.345

8. Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives.

Authors: Sangtae Oh; In Howa Jeong; Woon-Seob Shin; Seokjoon Lee
Journal: Bioorg Med Chem Lett Date: 2004-07-16 Impact factor: 2.823

Review 9. Artemisinin derivatives: toxic for laboratory animals, safe for humans?

Authors: Toufigh Gordi; Eve Irene Lepist
Journal: Toxicol Lett Date: 2004-03-01 Impact factor: 4.372

10. Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives.

Authors: Sangtae Oh; In Howa Jeong; Chan Mug Ahn; Woon-Seob Shin; Seokjoon Lee
Journal: Bioorg Med Chem Date: 2004-07-15 Impact factor: 3.641

2 in total

1. Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Authors: Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal: J Med Chem Date: 2012-08-27 Impact factor: 7.446

2. Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin.

Authors: Gab-Man Park; Hyun Park; Sangtae Oh; Seokjoon Lee
Journal: Korean J Parasitol Date: 2017-12-31 Impact factor: 1.341

2 in total