Literature DB >> 9871697

Stability of acetal and non acetal-type analogs of artemisinin in simulated stomach acid.

M Jung1, S Lee.   

Abstract

A series of non acetal-type analogs of artemisinin containing C-C bond at position-12 have been found to be 15-22 times more stable than acetal(C-O)-type prodrugs of artemisinin in simulated stomach acid.

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Year:  1998        PMID： 9871697     DOI： 10.1016/s0960-894x(98)00160-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Anti-Helicobacter pylori potential of artemisinin and its derivatives.

Authors:  Suchandra Goswami; Rajendra S Bhakuni; Annalakshmi Chinniah; Anirban Pal; Sudip K Kar; Pratap K Das
Journal:  Antimicrob Agents Chemother       Date:  2012-06-11       Impact factor: 5.191

2.  Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Authors:  Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  J Med Chem       Date:  2012-08-27       Impact factor: 7.446

3.  Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.

Authors:  Seokjoon Lee; Sangtae Oh; Gab-Man Park; Tong-Soo Kim; Jae-Sook Ryu; Han-Kyu Choi
Journal:  Korean J Parasitol       Date:  2005-09       Impact factor: 1.341

4.  A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Authors:  Deuk Kyu Moon; Abhai Tripathi; David Sullivan; Maxime A Siegler; Sean Parkin; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2010-09-29       Impact factor: 2.823

5.  Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Authors:  Ryan C Conyers; Jennifer R Mazzone; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2014-11-27       Impact factor: 2.823

6.  Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin.

Authors:  Gab-Man Park; Hyun Park; Sangtae Oh; Seokjoon Lee
Journal:  Korean J Parasitol       Date:  2017-12-31       Impact factor: 1.341
  6 in total

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