Literature DB >> 10896113

Antimalarial sulfide, sulfone, and sulfonamide trioxanes.

G H Posner1, J P Maxwell, H O'Dowd, M Krasavin, S Xie, T A Shapiro.   

Abstract

A series of trioxanes featuring sulfide, sulfone, and sulfonamide substituents in diverse positions has been prepared. Structure-activity relationship (SAR) generalizations highlight two major factors controlling the antimalarial potency of these new chemical entities: (1) the proximity of the sulfur-containing substituent to the crucial peroxide bond and (2) the oxidation state of the sulfur-containing substituent. Generally, sulfones are more antimalarially potent than the corresponding sulfides.

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Year:  2000        PMID： 10896113     DOI： 10.1016/s0968-0896(00)00079-1

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  QSAR for anti-malarial activity of 2-aziridinyl and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives.

Authors:  Mohamed Zahouily; Mohamed Lazar; Abdelhakim Elmakssoudi; Jamila Rakik; Sanaa Elaychi; A Rayadh
Journal:  J Mol Model       Date:  2005-12-09       Impact factor: 1.810

2.  Synthesis and antimalarial activity of 3,3-spiroanellated 5,6-disubstituted 1,2,4-trioxanes.

Authors:  Ranjani Maurya; Awakash Soni; Devireddy Anand; Makthala Ravi; Kanumuri S R Raju; Isha Taneja; Niraj K Naikade; S K Puri; Sanjeev Kanojiya; Prem P Yadav
Journal:  ACS Med Chem Lett       Date:  2012-12-11       Impact factor: 4.345

3.  Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.

Authors:  Seokjoon Lee; Sangtae Oh; Gab-Man Park; Tong-Soo Kim; Jae-Sook Ryu; Han-Kyu Choi
Journal:  Korean J Parasitol       Date:  2005-09       Impact factor: 1.341

4.  Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Authors:  Andrew S Rosenthal; Xiaochun Chen; Jun O Liu; Diana C West; Paul J Hergenrother; Theresa A Shapiro; Gary H Posner
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

Review 5.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883

6.  A green strategy for the synthesis of sulfone derivatives of p-methylaminophenol: Kinetic evaluation and antibacterial susceptibility.

Authors:  Davood Nematollahi; Sadegh Khazalpour; Mina Ranjbar; Shima Momeni
Journal:  Sci Rep       Date:  2017-06-30       Impact factor: 4.379

7.  Design and synthesis of new N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes.

Authors:  Nubia Boechat; Luiz C S Pinheiro; Osvaldo A Santos-Filho; Isabor C Silva
Journal:  Molecules       Date:  2011-09-20       Impact factor: 4.411

8.  New peptide derived antimalaria and antimicrobial agents bearing sulphonamide moiety.

Authors:  D I Ugwuja; U C Okoro; S S Soman; R Soni; S N Okafor; D I Ugwu
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  8 in total

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