Literature DB >> 16187096

Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites.

Laura J Walton1, Christophe Corre, Gregory L Challis.   

Abstract

Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.

Entities:  

Mesh:

Substances:

Year:  2005        PMID: 16187096     DOI: 10.1007/s10295-005-0026-7

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN: 1367-5435            Impact factor:   3.346


  39 in total

Review 1.  Biosynthesis of marine natural products: microorganisms and macroalgae.

Authors:  B S Moore
Journal:  Nat Prod Rep       Date:  1999-12       Impact factor: 13.423

2.  Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.

Authors:  Brian J Carroll; Steven J Moss; Linquan Bai; Yasuo Kato; Sabine Toelzer; Tin-Wein Yu; Heinz G Floss
Journal:  J Am Chem Soc       Date:  2002-04-24       Impact factor: 15.419

3.  Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

Authors:  James Ligon; Steven Hill; James Beck; Ross Zirkle; István Molnár; Jennifer Zawodny; Stephanie Money; Thomas Schupp
Journal:  Gene       Date:  2002-02-20       Impact factor: 3.688

4.  A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes.

Authors:  T Schupp; C Toupet; B Cluzel; S Neff; S Hill; J J Beck; J M Ligon
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

5.  Biosynthetic origin of the C2 units of geldanamycin and distribution of label from D-[6-13C]glucose.

Authors:  A Haber; R D Johnson; K L Rinehart
Journal:  J Am Chem Soc       Date:  1977-05-11       Impact factor: 15.419

6.  A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles.

Authors:  Jörn Piel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-14       Impact factor: 11.205

7.  Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B.

Authors:  Yasuo Kato; Linquan Bai; Qun Xue; W Peter Revill; Tin-Wein Yu; Heinz G Floss
Journal:  J Am Chem Soc       Date:  2002-05-15       Impact factor: 15.419

8.  The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Authors:  K Wu; L Chung; W P Revill; L Katz; C D Reeves
Journal:  Gene       Date:  2000-06-13       Impact factor: 3.688

9.  The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase.

Authors:  Annette Cronin; Sherry Mowbray; Heike Dürk; Shirli Homburg; Ingrid Fleming; Beate Fisslthaler; Franz Oesch; Michael Arand
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-06       Impact factor: 11.205

10.  SCP1, a 356,023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2).

Authors:  S D Bentley; S Brown; L D Murphy; D E Harris; M A Quail; J Parkhill; B G Barrell; J R McCormick; R I Santamaria; R Losick; M Yamasaki; H Kinashi; C W Chen; G Chandra; D Jakimowicz; H M Kieser; T Kieser; K F Chater
Journal:  Mol Microbiol       Date:  2004-03       Impact factor: 3.501

View more
  7 in total

Review 1.  Biosynthesis of polyketide synthase extender units.

Authors:  Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal:  Nat Prod Rep       Date:  2009-01       Impact factor: 13.423

2.  Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose.

Authors:  Yang Gao; Yuxiang Fan; Komi Nambou; Liujing Wei; Zhijie Liu; Tadayuki Imanaka; Qiang Hua
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-31       Impact factor: 3.346

3.  Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.

Authors:  Yunlong He; Yuhui Sun; Tiangang Liu; Xiufen Zhou; Linquan Bai; Zixin Deng
Journal:  Appl Environ Microbiol       Date:  2010-03-26       Impact factor: 4.792

4.  Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.

Authors:  Yolande A Chan; Michael T Boyne; Angela M Podevels; Amy K Klimowicz; Jo Handelsman; Neil L Kelleher; Michael G Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-18       Impact factor: 11.205

5.  Formation and characterization of acyl carrier protein-linked polyketide synthase extender units.

Authors:  Yolande A Chan; Michael G Thomas
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

6.  Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Authors:  Wei Zhang; Jeffrey L Fortman; Jacob C Carlson; Jinyong Yan; Yi Liu; Fali Bai; Wenna Guan; Junyong Jia; Teatulohi Matainaho; David H Sherman; Shengying Li
Journal:  Chembiochem       Date:  2013-01-29       Impact factor: 3.164

7.  COX Inhibitory and Cytotoxic Naphthoketal-Bearing Polyketides from Sparticola junci.

Authors:  Katherine Yasmin M Garcia; Mark Tristan J Quimque; Gian Primahana; Andreas Ratzenböck; Mark Joseph B Cano; Jeremiah Francis A Llaguno; Hans-Martin Dahse; Chayanard Phukhamsakda; Frank Surup; Marc Stadler; Allan Patrick G Macabeo
Journal:  Int J Mol Sci       Date:  2021-11-17       Impact factor: 5.923

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.