OBJECTIVE: To test the a priori hypothesis of HIV-1 transmission from one suspect to six recipients in a criminal case. METHODS: Partial pol and/or env sequences were obtained for at least two samples of the suspect and the victims. Appropriate local controls were sampled based on epidemiological and subtype criteria. Phylogenetic testing was performed using different reconstruction methods. RESULTS: Phylogenetic analyses consistently inferred a monophyletic cluster for the suspect and victim samples in both genome regions. This was highly supported by parametric and non-parametric bootstrapping techniques. Moreover, the controls most closely related to the suspect-victim cluster had a similar geographical origin to the suspect. CONCLUSIONS: Taking into account the limitations on the conclusions that can be drawn from molecular investigations we could infer that our molecular data is consistent with a scenario of multiple HIV transmission between suspect and victims.
OBJECTIVE: To test the a priori hypothesis of HIV-1 transmission from one suspect to six recipients in a criminal case. METHODS: Partial pol and/or env sequences were obtained for at least two samples of the suspect and the victims. Appropriate local controls were sampled based on epidemiological and subtype criteria. Phylogenetic testing was performed using different reconstruction methods. RESULTS: Phylogenetic analyses consistently inferred a monophyletic cluster for the suspect and victim samples in both genome regions. This was highly supported by parametric and non-parametric bootstrapping techniques. Moreover, the controls most closely related to the suspect-victim cluster had a similar geographical origin to the suspect. CONCLUSIONS: Taking into account the limitations on the conclusions that can be drawn from molecular investigations we could infer that our molecular data is consistent with a scenario of multiple HIV transmission between suspect and victims.
Authors: Diane I Scaduto; Jeremy M Brown; Wade C Haaland; Derrick J Zwickl; David M Hillis; Michael L Metzker Journal: Proc Natl Acad Sci U S A Date: 2010-11-15 Impact factor: 11.205
Authors: Martin Stürmer; Katrin Zimmermann; Carlos Fritzsche; Emil Reisinger; Gottfried Doelken; Annemarie Berger; Hans W Doerr; Josef Eberle; Lutz G Gürtler Journal: Med Microbiol Immunol Date: 2010-03-09 Impact factor: 3.402
Authors: Ann M Dennis; Joshua T Herbeck; Andrew L Brown; Paul Kellam; Tulio de Oliveira; Deenan Pillay; Christophe Fraser; Myron S Cohen Journal: J Acquir Immune Defic Syndr Date: 2014-10-01 Impact factor: 3.731
Authors: Cordelia E M Coltart; Anne Hoppe; Michael Parker; Liza Dawson; Joseph J Amon; Musonda Simwinga; Gail Geller; Gail Henderson; Oliver Laeyendecker; Joseph D Tucker; Patrick Eba; Vladimir Novitsky; Anne-Mieke Vandamme; Janet Seeley; Gina Dallabetta; Guy Harling; M Kate Grabowski; Peter Godfrey-Faussett; Christophe Fraser; Myron S Cohen; Deenan Pillay Journal: Lancet HIV Date: 2018-08-30 Impact factor: 12.767