Literature DB >> 16178557

Small molecule macroarray construction via Ugi four-component reactions.

Qi Lin1, Jennifer C O'Neill, Helen E Blackwell.   

Abstract

[reaction: see text] We report the construction of small molecule macroarrays via Ugi four-component reactions on planar cellulose supports. Array synthesis was enabled by the development of a high efficiency photocleavable linker system and the strategic use of both water- and microwave-assisted organic reactions.

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Year:  2005        PMID： 16178557     DOI： 10.1021/ol051684o

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.

Authors:  Zhang Liu; Adel Nefzi
Journal:  J Comb Chem       Date:  2010-07-12

3.  Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports.

Authors:  Qi Lin; Helen E Blackwell
Journal:  Chem Commun (Camb)       Date:  2006-07-21       Impact factor: 6.222

4.  Efficient construction of diketopiperazine macroarrays through a cyclative-cleavage strategy and their evaluation as luminescence inhibitors in the bacterial symbiont Vibrio fischeri.

Authors:  Jennifer Campbell; Helen E Blackwell
Journal:  J Comb Chem       Date:  2009 Nov-Dec

Review 5.  Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential.

Authors:  Jennifer C O'Neill; Helen E Blackwell
Journal:  Comb Chem High Throughput Screen       Date:  2007-12       Impact factor: 1.339

Review 6.  Organic synthesis "on water".

Authors:  Arani Chanda; Valery V Fokin
Journal:  Chem Rev       Date:  2009-02       Impact factor: 60.622

7.  Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays.

Authors:  Thanit Praneenararat; Grant D Geske; Helen E Blackwell
Journal:  Org Lett       Date:  2009-10-15       Impact factor: 6.005

8.  Chemical methods to interrogate bacterial quorum sensing pathways.

Authors:  Thanit Praneenararat; Andrew G Palmer; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2012-10-03       Impact factor: 3.876

9.  Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing.

Authors:  Reto Frei; Anthony S Breitbach; Helen E Blackwell
Journal:  Chem Sci       Date:  2012-05       Impact factor: 9.825

10.  Rapid Discovery and Structure-Property Relationships of Metal-Ion Fluorescent Sensors via Macroarray Synthesis.

Authors:  Apiwat Promchat; Kanet Wongravee; Mongkol Sukwattanasinitt; Thanit Praneenararat
Journal:  Sci Rep       Date:  2019-07-17       Impact factor: 4.379
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