Literature DB >> 19743816

Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays.

Thanit Praneenararat1, Grant D Geske, Helen E Blackwell.   

Abstract

A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.

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Year:  2009        PMID： 19743816      PMCID： PMC3175425          DOI： 10.1021/ol901871y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  18 in total

Review 1.  Regulatory circuits and communication in Gram-negative bacteria.

Authors:  Andrée M Lazdunski; Isabelle Ventre; James N Sturgis
Journal:  Nat Rev Microbiol       Date:  2004-07       Impact factor: 60.633

2.  Microwave-accelerated SPOT-synthesis on cellulose supports.

Authors:  Matthew D Bowman; Ryan C Jeske; Helen E Blackwell
Journal:  Org Lett       Date:  2004-06-10       Impact factor: 6.005

3.  Small molecule macroarray construction via Ugi four-component reactions.

Authors:  Qi Lin; Jennifer C O'Neill; Helen E Blackwell
Journal:  Org Lett       Date:  2005-09-29       Impact factor: 6.005

Review 4.  Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis.

Authors:  Helen E Blackwell
Journal:  Curr Opin Chem Biol       Date:  2006-05-06       Impact factor: 8.822

5.  Deciphering a protolanguage for bacteria-host communication.

Authors:  Andrew G Palmer; Helen E Blackwell
Journal:  Nat Chem Biol       Date:  2008-08       Impact factor: 15.040

6.  Extraction of violacein from Chromobacterium violaceum provides a new quantitative bioassay for N-acyl homoserine lactone autoinducers.

Authors:  R S Blosser; K M Gray
Journal:  J Microbiol Methods       Date:  2000-03       Impact factor: 2.363

7.  Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

Authors:  Kay H McClean; Michael K Winson; Leigh Fish; Adrian Taylor; Siri Ram Chhabra; Miguel Camara; Mavis Daykin; John H Lamb; Simon Swift; Barrie W Bycroft; Gordon S A B Stewart; Paul Williams
Journal:  Microbiology (Reading)       Date:  1997-12       Impact factor: 2.777

8.  Structural identification of autoinducer of Photobacterium fischeri luciferase.

Authors:  A Eberhard; A L Burlingame; C Eberhard; G L Kenyon; K H Nealson; N J Oppenheimer
Journal:  Biochemistry       Date:  1981-04-28       Impact factor: 3.162

Review 9.  Cell-cell communication in Gram-negative bacteria.

Authors:  Martin Welch; Helga Mikkelsen; Jane E Swatton; Debra Smith; Gemma L Thomas; Freija G Glansdorp; David R Spring
Journal:  Mol Biosyst       Date:  2005-07-25

Review 10.  Bacterial small-molecule signaling pathways.

Authors:  Andrew Camilli; Bonnie L Bassler
Journal:  Science       Date:  2006-02-24       Impact factor: 47.728
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  14 in total

1.  Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts.

Authors:  Andrew G Palmer; Evan Streng; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2011-10-06       Impact factor: 5.100

2.  Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa.

Authors:  Nora R Eibergen; Joseph D Moore; Margrith E Mattmann; Helen E Blackwell
Journal:  Chembiochem       Date:  2015-10-13       Impact factor: 3.164

3.  Potent and selective synthetic modulators of a quorum sensing repressor in Pseudomonas aeruginosa identified from second-generation libraries of N-acylated L-homoserine lactones.

Authors:  Margrith E Mattmann; Patrick M Shipway; Nicole J Heth; Helen E Blackwell
Journal:  Chembiochem       Date:  2011-03-01       Impact factor: 3.164

4.  Thiolactone modulators of quorum sensing revealed through library design and screening.

Authors:  Christine E McInnis; Helen E Blackwell
Journal:  Bioorg Med Chem       Date:  2011-07-01       Impact factor: 3.641

5.  Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing.

Authors:  Christine E McInnis; Helen E Blackwell
Journal:  Bioorg Med Chem       Date:  2011-07-01       Impact factor: 3.641

Review 6.  Chromobacterium violaceum and its important metabolites--review.

Authors:  M Durán; A Faljoni-Alario; N Durán
Journal:  Folia Microbiol (Praha)       Date:  2011-01-21       Impact factor: 2.099

7.  Quorum sensing in bacterial species that use degenerate autoinducers can be tuned by using structurally identical non-native ligands.

Authors:  Andrew G Palmer; Evan Streng; Kelsea A Jewell; Helen E Blackwell
Journal:  Chembiochem       Date:  2011-01-03       Impact factor: 3.164

8.  Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.

Authors:  Danielle M Stacy; Sebastian T Le Quement; Casper L Hansen; Janie W Clausen; Tim Tolker-Nielsen; Jacob W Brummond; Michael Givskov; Thomas E Nielsen; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2012-12-20       Impact factor: 3.876

9.  Selection of Appropriate Autoinducer Analogues for the Modulation of Quorum Sensing at the Host-Bacterium Interface.

Authors:  Andrew G Palmer; Amanda C Senechal; Timothy C Haire; Nidhi P Mehta; Sara D Valiquette; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2018-10-18       Impact factor: 5.100

10.  Chemical methods to interrogate bacterial quorum sensing pathways.

Authors:  Thanit Praneenararat; Andrew G Palmer; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2012-10-03       Impact factor: 3.876
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