PURPOSE: To examine the prevalence of osteopenia and/or osteoporosis among African Americans with early rheumatoid arthritis (RA) and to assess the effect of using race/ethnicity-specific normative data. METHODS: Bone mineral density (BMD) of the hip and spine was assessed in African Americans with early RA. To examine the impact of using different normative data on disease classification, we calculated two sets of T scores, the first using sex-matched reference data from Caucasians and the second using data from African Americans. Osteoporosis was defined as a BMD at either site > or =2.5 SD below the young adult mean. Osteopenia was defined as a BMD > or =1 SD and <2.5 SD below this mean. RESULTS: Using Caucasian referent data, 33% (n=48) of patients had osteopenia or worse (n=48, 32.9%) and 5% (n=8) were osteoporotic. With the use of African-American normative data, 55% (n=94) were osteopenic or worse, and 16% (n=27) were osteoporotic. CONCLUSION: African Americans with RA are at risk of osteopenia and/or osteoporosis. Different diagnostic classifications may occur in this population based solely on the normative data used for assessing fracture risk. These results underscore the need for a standardized approach in defining osteopenia and osteoporosis in African Americans.
PURPOSE: To examine the prevalence of osteopenia and/or osteoporosis among African Americans with early rheumatoid arthritis (RA) and to assess the effect of using race/ethnicity-specific normative data. METHODS: Bone mineral density (BMD) of the hip and spine was assessed in African Americans with early RA. To examine the impact of using different normative data on disease classification, we calculated two sets of T scores, the first using sex-matched reference data from Caucasians and the second using data from African Americans. Osteoporosis was defined as a BMD at either site > or =2.5 SD below the young adult mean. Osteopenia was defined as a BMD > or =1 SD and <2.5 SD below this mean. RESULTS: Using Caucasian referent data, 33% (n=48) of patients had osteopenia or worse (n=48, 32.9%) and 5% (n=8) were osteoporotic. With the use of African-American normative data, 55% (n=94) were osteopenic or worse, and 16% (n=27) were osteoporotic. CONCLUSION: African Americans with RA are at risk of osteopenia and/or osteoporosis. Different diagnostic classifications may occur in this population based solely on the normative data used for assessing fracture risk. These results underscore the need for a standardized approach in defining osteopenia and osteoporosis in African Americans.
Authors: F C Arnett; S M Edworthy; D A Bloch; D J McShane; J F Fries; N S Cooper; L A Healey; S R Kaplan; M H Liang; H S Luthra Journal: Arthritis Rheum Date: 1988-03
Authors: H K Genant; S Grampp; C C Glüer; K G Faulkner; M Jergas; K Engelke; S Hagiwara; C Van Kuijk Journal: J Bone Miner Res Date: 1994-10 Impact factor: 6.741
Authors: Leon Lenchik; Edward S Leib; Ronald C Hamdy; Neil C Binkley; Paul D Miller; Nelson B Watts Journal: J Clin Densitom Date: 2002 Impact factor: 2.963
Authors: Jie Zhang; David T Redden; Gerald McGwin; Leigh F Callahan; Edwin A Smith; Graciela S Alarcón; Larry W Moreland; Désirée M van der Heijde; Elizabeth E Brown; Donna K Arnett; Ted R Mikuls; S Louis Bridges Journal: Arthritis Rheum Date: 2010-08
Authors: Ted R Mikuls; Harlan Sayles; Fang Yu; Tricia Levan; Karen A Gould; Geoffrey M Thiele; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin Smith; Richard Brasington; Larry W Moreland; Richard J Reynolds; S Louis Bridges Journal: Arthritis Rheum Date: 2010-12
Authors: Ted R Mikuls; Tricia Levan; Karen A Gould; Fang Yu; Geoffrey M Thiele; Kimberly K Bynote; Doyt Conn; Beth L Jonas; Leigh F Callahan; Edwin Smith; Richard Brasington; Larry W Moreland; Richard Reynolds; Angelo Gaffo; S Louis Bridges Journal: Arthritis Rheum Date: 2012-03
Authors: Z Chen; M T Salam; R Karim; C M Toledo-Corral; R M Watanabe; A H Xiang; T A Buchanan; R Habre; T M Bastain; F Lurmann; M Taher; J P Wilson; E Trigo; F D Gilliland Journal: Osteoporos Int Date: 2015-02-13 Impact factor: 4.507
Authors: T R Mikuls; L B Hughes; A O Westfall; V M Holers; L Parrish; D van der Heijde; M van Everdingen; G S Alarcón; D L Conn; B Jonas; L F Callahan; E A Smith; G Gilkeson; G Howard; L W Moreland; S L Bridges Journal: Ann Rheum Dis Date: 2008-01-15 Impact factor: 19.103