OBJECTIVE: To examine the association between baseline bone mineral density (BMD) and radiographic damage at 3 years of disease duration in a longitudinal cohort of African Americans with recent-onset rheumatoid arthritis (RA). METHODS: African American RA patients with a disease duration of <2 years (n = 141) were included in the study. All patients underwent baseline BMD measurements (femoral neck and/or lumbar spine) using dual x-ray absorptiometry. T scores were calculated using normative data from the general population of African Americans. Patients were categorized as having osteopenia/osteoporosis (T score less than or equal to -1) or as being healthy. Hand and wrist radiographs, obtained at baseline and at 3 years of disease duration, were scored using the modified Sharp/van der Heijde method. The association between baseline BMD and total radiographic score at 3 years of disease was examined using multivariable negative binomial regression. RESULTS: At baseline, the mean age and the mean disease duration were 52.4 years and 14.8 months, respectively; 85.1% of the patients were women. The average total radiographic scores at baseline and at 3 years of disease were 2.4 and 5.7, respectively. In the final reduced multivariable model, adjusting for age, sex, anti-cyclic citrullinated peptide antibody positivity, and the presence of radiographic damage at baseline, the total radiographic score at 3 years disease in patients with osteopenia/osteoporosis of the femoral neck was twice that in patients with normal bone density, and the difference was statistically significant (P = 0.0084). No association between lumbar spine osteopenia/osteoporosis and radiographic score was found. CONCLUSION: Our findings suggest that reduced generalized BMD may be a predictor of future radiographic damage and support the hypothesis that radiographic damage and reduced generalized BMD in RA patients may share a common pathogenic mechanism.
OBJECTIVE: To examine the association between baseline bone mineral density (BMD) and radiographic damage at 3 years of disease duration in a longitudinal cohort of African Americans with recent-onset rheumatoid arthritis (RA). METHODS: African American RApatients with a disease duration of <2 years (n = 141) were included in the study. All patients underwent baseline BMD measurements (femoral neck and/or lumbar spine) using dual x-ray absorptiometry. T scores were calculated using normative data from the general population of African Americans. Patients were categorized as having osteopenia/osteoporosis (T score less than or equal to -1) or as being healthy. Hand and wrist radiographs, obtained at baseline and at 3 years of disease duration, were scored using the modified Sharp/van der Heijde method. The association between baseline BMD and total radiographic score at 3 years of disease was examined using multivariable negative binomial regression. RESULTS: At baseline, the mean age and the mean disease duration were 52.4 years and 14.8 months, respectively; 85.1% of the patients were women. The average total radiographic scores at baseline and at 3 years of disease were 2.4 and 5.7, respectively. In the final reduced multivariable model, adjusting for age, sex, anti-cyclic citrullinated peptide antibody positivity, and the presence of radiographic damage at baseline, the total radiographic score at 3 years disease in patients with osteopenia/osteoporosis of the femoral neck was twice that in patients with normal bone density, and the difference was statistically significant (P = 0.0084). No association between lumbar spine osteopenia/osteoporosis and radiographic score was found. CONCLUSION: Our findings suggest that reduced generalized BMD may be a predictor of future radiographic damage and support the hypothesis that radiographic damage and reduced generalized BMD in RApatients may share a common pathogenic mechanism.
Authors: F Cosman; D C Morgan; J W Nieves; V Shen; M M Luckey; D W Dempster; R Lindsay; M Parisien Journal: J Bone Miner Res Date: 1997-06 Impact factor: 6.741
Authors: M C Wang; M Aguirre; G S Bhudhikanok; C G Kendall; S Kirsch; R Marcus; L K Bachrach Journal: J Bone Miner Res Date: 1997-11 Impact factor: 6.741
Authors: H K Genant; S Grampp; C C Glüer; K G Faulkner; M Jergas; K Engelke; S Hagiwara; C Van Kuijk Journal: J Bone Miner Res Date: 1994-10 Impact factor: 6.741
Authors: Marshall L R Davis; Kaleb Michaud; Harlan Sayles; Doyt L Conn; Larry W Moreland; S Louis Bridges; Ted R Mikuls Journal: J Rheumatol Date: 2013-06-15 Impact factor: 4.666
Authors: Eman A Hafez; Howaida E Mansour; Sherin H Hamza; Sherine George Moftah; Takwa Badr Younes; Mona Ahmed Ismail Journal: Clin Med Insights Arthritis Musculoskelet Disord Date: 2011-10-09