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Literature DB >> 16163478

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy.

Dheeraj Malhotra¹, Katayoon Darvishi, Soni Sood, Swarkar Sharma, Chander Grover, Vineet Relhan, B S N Reddy, R N K Bamezai.

Abstract

The minor haplotype -3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: -3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37-0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype -3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype -3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16163478 DOI： 10.1007/s00439-005-0042-8

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

15 in total

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Authors: Milton O Moraes; Adalberto R Santos; Joris J M Schonkeren; Patrícia R Vanderborght; Tom H M Ottenhoff; Maria E Moraes; José R Moraes; Elizabeth P Sampaio; Euzenir N Sarno; Tom W J Huizinga
Journal: Immunogenetics Date: 2003-03-05 Impact factor: 2.846

Review 2. Genetics of susceptibility to leprosy.

Authors: J Fitness; K Tosh; A V S Hill
Journal: Genes Immun Date: 2002-12 Impact factor: 2.676

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Journal: Nature Date: 2004-01-25 Impact factor: 49.962

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Journal: Eur J Immunogenet Date: 1997-02

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Journal: Scand J Immunol Date: 2000-04 Impact factor: 3.487

6. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus.

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7. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae.

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Journal: FEMS Immunol Med Microbiol Date: 2004-09-01

9. Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy.

Authors: Adalberto R Santos; Philip N Suffys; Patrícia R Vanderborght; Milton O Moraes; Leila M M Vieira; Pedro H Cabello; Aleida M Bakker; Haroldo J Matos; Tom W J Huizinga; Tom H M Ottenhoff; Elizabeth P Sampaio; Euzenir N Sarno
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Authors: M O Moraes; A G Pacheco; J J M Schonkeren; P R Vanderborght; J A C Nery; A R Santos; M E Moraes; J R Moraes; T H M Ottenhoff; E P Sampaio; T W J Huizinga; E N Sarno
Journal: Genes Immun Date: 2004-11 Impact factor: 2.676

18 in total

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Authors: Shafat Ali; Rupali Chopra; Shweta Aggarwal; Amit Kumar Srivastava; Ponnusamy Kalaiarasan; Dheeraj Malhotra; Sailesh Gochhait; Vijay K Garg; S N Bhattacharya; Rameshwar N K Bamezai
Journal: Hum Genet Date: 2011-11-10 Impact factor: 4.132

2. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.

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Review 3. Leprosy and the human genome.

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Journal: Microbiol Mol Biol Rev Date: 2010-12 Impact factor: 11.056

4. IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.

Authors: C C Cardoso; A C Pereira; V N Brito-de-Souza; I M Dias-Baptista; V C Maniero; J Venturini; F R Vilani-Moreno; F C de Souza; M Ribeiro-Alves; E N Sarno; A G Pacheco; M O Moraes
Journal: Hum Genet Date: 2010-08-17 Impact factor: 4.132

5. Leprosy and the adaptation of human toll-like receptor 1.

Authors: Sunny H Wong; Sailesh Gochhait; Dheeraj Malhotra; Fredrik H Pettersson; Yik Y Teo; Chiea C Khor; Anna Rautanen; Stephen J Chapman; Tara C Mills; Amit Srivastava; Aleksey Rudko; Maxim B Freidin; Valery P Puzyrev; Shafat Ali; Shweta Aggarwal; Rupali Chopra; Belum S N Reddy; Vijay K Garg; Suchismita Roy; Sarah Meisner; Sunil K Hazra; Bibhuti Saha; Sian Floyd; Brendan J Keating; Cecilia Kim; Benjamin P Fairfax; Julian C Knight; Philip C Hill; Richard A Adegbola; Hakon Hakonarson; Paul E M Fine; Ramasamy M Pitchappan; Rameshwar N K Bamezai; Adrian V S Hill; Fredrik O Vannberg
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6. Haplotypes of the IL10 gene as potential protection factors in leprosy patients.

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