Literature DB >> 16157477

Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro.

A Mayr1, G Hinterberger, M P Dierich, C Lass-Flörl.   

Abstract

In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118-0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.

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Year:  2005        PMID： 16157477      PMCID： PMC2980867          DOI： 10.1016/j.ijantimicag.2005.07.006

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  14 in total

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