| Literature DB >> 16153408 |
Tsutomu Hatano1, Miwako Kusuda, Kazutoshi Inada, Tomo-omi Ogawa, Sumiko Shiota, Tomofusa Tsuchiya, Takashi Yoshida.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a beta-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.Entities:
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Year: 2005 PMID： 16153408 DOI： 10.1016/j.phytochem.2005.01.013
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072