| Literature DB >> 16146776 |
Samuel C Chang1, Tracy Tucker, Nancy P Thorogood, Carolyn J Brown.
Abstract
Mammalian X-chromosome inactivation is an impressive example of epigenetic gene regulation, whereby the majority of genes on the approximately 160 Mb X chromosome are silenced in a strictly cis-limited fashion. In this review we will discuss the important players involved in the silencing process. The process is initiated by transcription and cis-localization of the non-coding XIST RNA, which then recruits many of the epigenetic features generally associated with heterochromatin, including histone modifications, histone variants and DNA methylation.Entities:
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Year: 2006 PMID: 16146776 DOI: 10.2741/1842
Source DB: PubMed Journal: Front Biosci ISSN: 1093-4715