BACKGROUND: The final common pathway for open angle glaucoma (OAG) is retinal ganglion cell apoptosis. Polymorphisms in p53, a major regulator of apoptosis, affect the efficiency of cell death induction. Association studies of p53 haplotypes and OAG have had conflicting results. OBJECTIVE: To examine the association between p53 haplotypes and OAG in a larger white population than in previous reports, and extend the analysis to normal tension glaucoma. METHODS: 345 unrelated people with OAG were recruited (283 subjects with high tension glaucoma and 62 with normal tension glaucoma) and compared with 178 age matched controls. Genomic DNA was analysed for the p53 codon 72 Arg/Pro polymorphism as well as for the presence or absence of a 16 bp intron 3 insertion. RESULTS: In this white cohort no association was found between glaucoma (high or normal tension) and either sequence variant or haplotype. CONCLUSIONS: The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma.
BACKGROUND: The final common pathway for open angle glaucoma (OAG) is retinal ganglion cell apoptosis. Polymorphisms in p53, a major regulator of apoptosis, affect the efficiency of cell death induction. Association studies of p53 haplotypes and OAG have had conflicting results. OBJECTIVE: To examine the association between p53 haplotypes and OAG in a larger white population than in previous reports, and extend the analysis to normal tension glaucoma. METHODS: 345 unrelated people with OAG were recruited (283 subjects with high tension glaucoma and 62 with normal tension glaucoma) and compared with 178 age matched controls. Genomic DNA was analysed for the p53 codon 72 Arg/Pro polymorphism as well as for the presence or absence of a 16 bp intron 3 insertion. RESULTS: In this white cohort no association was found between glaucoma (high or normal tension) and either sequence variant or haplotype. CONCLUSIONS: The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma.
Authors: Christopher L Daugherty; Hilda Curtis; Tony Realini; Judie F Charlton; Sepideh Zareparsi Journal: Mol Vis Date: 2009-09-22 Impact factor: 2.367
Authors: Janey L Wiggs; Alex W Hewitt; Bao Jian Fan; Dan Yi Wang; Dayse R Figueiredo Sena; Colm O'Brien; Anthony Realini; Jamie E Craig; David P Dimasi; David A Mackey; Jonathan L Haines; Louis R Pasquale Journal: PLoS One Date: 2012-09-26 Impact factor: 3.240
Authors: Bao Jian Fan; Dan Yi Wang; Ching-Yu Cheng; Wendy Charles Ko; Shun Chiu Lam; Chi Pui Pang Journal: Mol Vis Date: 2009-04-03 Impact factor: 2.367