Literature DB >> 16127079

Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).

Jun-ichiro Sekiguchi1, Prasit Tharavichitkul, Tohru Miyoshi-Akiyama, Vena Chupia, Tomoko Fujino, Minako Araake, Atsushi Irie, Koji Morita, Tadatoshi Kuratsuji, Teruo Kirikae.   

Abstract

A novel gene, dfrG, encoding a trimethoprim (TMP)-resistant dihydrofolate reductase (DHFR, designated S3DHFR) was cloned from a clinical isolate of methicillin-resistant Staphylococcus aureus. Escherichia coli expressing dfrG was highly resistant to TMP. Recombinant S3DHFR exhibited DHFR activity that was not inhibited by TMP.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16127079      PMCID： PMC1195413          DOI： 10.1128/AAC.49.9.3948-3951.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Characterization of dihydrofolate reductase genes from trimethoprim-susceptible and trimethoprim-resistant strains of Enterococcus faecalis.

Authors:  T M Coque; K V Singh; G M Weinstock; B E Murray
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors:  M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
Journal:  Lancet       Date:  2001-04-21       Impact factor: 79.321

Review 3.  Trimethoprim and sulfonamide resistance.

Authors:  P Huovinen; L Sundström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

4.  A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

Authors:  G E Dale; C Broger; A D'Arcy; P G Hartman; R DeHoogt; S Jolidon; I Kompis; A M Labhardt; H Langen; H Locher; M G Page; D Stüber; R L Then; B Wipf; C Oefner
Journal:  J Mol Biol       Date:  1997-02-14       Impact factor: 5.469

5.  Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim.

Authors:  Esther W Barrow; Philip C Bourne; William W Barrow
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

6.  Characterization of the gene for chromosomal trimethoprim-sensitive dihydrofolate reductase of Staphylococcus aureus ATCC 25923.

Authors:  G E Dale; R L Then; D Stüber
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

7.  Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?

Authors:  G E Dale; C Broger; P G Hartman; H Langen; M G Page; R L Then; D Stüber
Journal:  J Bacteriol       Date:  1995-06       Impact factor: 3.490

8.  Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.

Authors:  G E Dale; H Langen; M G Page; R L Then; D Stüber
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

9.  Analysis of the conjugal transfer system of the pheromone-independent highly transferable Enterococcus plasmid pMG1: identification of a tra gene (traA) up-regulated during conjugation.

Authors:  Koichi Tanimoto; Yasuyoshi Ike
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

10.  Plasmid-encoded trimethoprim resistance in staphylococci.

Authors:  G L Archer; J P Coughter; J L Johnston
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191
View more
  20 in total

Review 1.  Antibacterial Antifolates: From Development through Resistance to the Next Generation.

Authors:  Alexavier Estrada; Dennis L Wright; Amy C Anderson
Journal:  Cold Spring Harb Perspect Med       Date:  2016-08-01       Impact factor: 6.915

2.  Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.

Authors:  Stephanie M Reeve; Debjani Si; Jolanta Krucinska; Yongzhao Yan; Kishore Viswanathan; Siyu Wang; Graham T Holt; Marcel S Frenkel; Adegoke A Ojewole; Alexavier Estrada; Sherry S Agabiti; Jeremy B Alverson; Nathan D Gibson; Nigel D Priestley; Andrew J Wiemer; Bruce R Donald; Dennis L Wright
Journal:  ACS Infect Dis       Date:  2019-10-15       Impact factor: 5.084

3.  Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus.

Authors:  Ricardo León-Sampedro; Carla Novais; Luísa Peixe; Fernando Baquero; Teresa M Coque
Journal:  Antimicrob Agents Chemother       Date:  2016-01-04       Impact factor: 5.191

4.  Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

Authors:  Stephanie M Reeve; Eric Scocchera; Jacob J Ferreira; Narendran G-Dayanandan; Santosh Keshipeddy; Dennis L Wright; Amy C Anderson
Journal:  J Med Chem       Date:  2016-06-28       Impact factor: 7.446

5.  Frequent occurrence of trimethoprim-sulfamethoxazole hetero-resistant Staphylococcus aureus isolates in different African countries.

Authors:  C Coelho; H de Lencastre; M Aires-de-Sousa
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-02-03       Impact factor: 3.267

6.  Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs.

Authors:  Catherine Clark; Lois M Ednie; Gengrong Lin; Kathy Smith; Klaudia Kosowska-Shick; Pamela McGhee; Bonifacio Dewasse; Linda Beachel; Patrick Caspers; Bérangère Gaucher; Gürkan Mert; Stuart Shapiro; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

7.  Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.

Authors:  Gabriel O Aboge; Honglin Jia; Mohamad A Terkawi; Youn-Kyoung Goo; Yoshifumi Nishikawa; Fujiko Sunaga; Kuzuhiko Namikawa; Naotoshi Tsuji; Ikuo Igarashi; Hiroshi Suzuki; Kozo Fujisaki; Xuenan Xuan
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191

8.  Factors that cause trimethoprim resistance in Streptococcus pyogenes.

Authors:  René Bergmann; Mark van der Linden; Gursharan S Chhatwal; D Patric Nitsche-Schmitz
Journal:  Antimicrob Agents Chemother       Date:  2014-02-03       Impact factor: 5.191

9.  Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L).

Authors:  Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

10.  DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.

Authors:  Anna C Shore; Orla M Brennan; Emily C Deasy; Angela S Rossney; Peter M Kinnevey; Ralf Ehricht; Stefan Monecke; David C Coleman
Journal:  Antimicrob Agents Chemother       Date:  2012-08-06       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.