Literature DB >> 19015335

Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L).

Kristina Kadlec1, Stefan Schwarz.   

Abstract

A novel trimethoprim resistance gene, designated dfrK, was detected in close proximity to the tetracycline resistance gene tet(L) on the ca. 40-kb plasmid pKKS2187 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The dfrK gene encodes a 163-amino-acid dihydrofolate reductase that differs from all so-far-known dihydrofolate reductases.

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Year:  2008        PMID： 19015335      PMCID： PMC2630608          DOI： 10.1128/AAC.01128-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant Staphylococcus aureus.

Authors:  Duarte C Oliveira; Alexander Tomasz; Hermínia de Lencastre
Journal:  Lancet Infect Dis       Date:  2002-03       Impact factor: 25.071

2.  Nucleotide sequence of the tetracycline resistance gene of pBC16 from Bacillus cereus.

Authors:  A Palva; G Vigren; M Simonen; H Rintala; P Laamanen
Journal:  Nucleic Acids Res       Date:  1990-03-25       Impact factor: 16.971

3.  Correction. A revision of the nucleotide sequence and functional map of pUB110.

Authors:  T McKenzie; T Hoshino; T Tanaka; N Sueoka
Journal:  Plasmid       Date:  1987-01       Impact factor: 3.466

4.  Integration of pT181-like tetracycline resistance plasmids into large staphylococcal plasmids involves IS257.

Authors:  C Werckenthin; S Schwarz; M C Roberts
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

5.  Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257.

Authors:  D A Rouch; L J Messerotti; L S Loo; C A Jackson; R A Skurray
Journal:  Mol Microbiol       Date:  1989-02       Impact factor: 3.501

6.  Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?

Authors:  G E Dale; C Broger; P G Hartman; H Langen; M G Page; R L Then; D Stüber
Journal:  J Bacteriol       Date:  1995-06       Impact factor: 3.490

7.  The large Bacillus plasmid pTB19 contains two integrated rolling-circle plasmids carrying mobilization functions.

Authors:  L Oskam; D J Hillenga; G Venema; S Bron
Journal:  Plasmid       Date:  1991-07       Impact factor: 3.466

8.  Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.

Authors:  G E Dale; H Langen; M G Page; R L Then; D Stüber
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

9.  Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.

Authors:  Matthew T G Holden; Edward J Feil; Jodi A Lindsay; Sharon J Peacock; Nicholas P J Day; Mark C Enright; Tim J Foster; Catrin E Moore; Laurence Hurst; Rebecca Atkin; Andrew Barron; Nathalie Bason; Stephen D Bentley; Carol Chillingworth; Tracey Chillingworth; Carol Churcher; Louise Clark; Craig Corton; Ann Cronin; Jon Doggett; Linda Dowd; Theresa Feltwell; Zahra Hance; Barbara Harris; Heidi Hauser; Simon Holroyd; Kay Jagels; Keith D James; Nicola Lennard; Alexandra Line; Rebecca Mayes; Sharon Moule; Karen Mungall; Douglas Ormond; Michael A Quail; Ester Rabbinowitsch; Kim Rutherford; Mandy Sanders; Sarah Sharp; Mark Simmonds; Kim Stevens; Sally Whitehead; Bart G Barrell; Brian G Spratt; Julian Parkhill
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-22       Impact factor: 11.205

10.  Identification and analysis of genes for tetracycline resistance and replication functions in the broad-host-range plasmid pLS1.

Authors:  S A Lacks; P Lopez; B Greenberg; M Espinosa
Journal:  J Mol Biol       Date:  1986-12-20       Impact factor: 5.469
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  29 in total

1.  Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain.

Authors:  Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2010-05-24       Impact factor: 5.191

2.  Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.

Authors:  Andrea T Fessler; Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

3.  Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.

Authors:  Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

4.  Characterization of methicillin-resistant Staphylococcus aureus isolates from food and food products of poultry origin in Germany.

Authors:  Andrea T Fessler; Kristina Kadlec; Melanie Hassel; Tomasz Hauschild; Christopher Eidam; Ralf Ehricht; Stefan Monecke; Stefan Schwarz
Journal:  Appl Environ Microbiol       Date:  2011-07-01       Impact factor: 4.792

Review 5.  Mobile Genetic Elements Associated with Antimicrobial Resistance.

Authors:  Sally R Partridge; Stephen M Kwong; Neville Firth; Slade O Jensen
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

6.  Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.

Authors:  Elena Gómez-Sanz; Kristina Kadlec; Andrea T Feßler; Myriam Zarazaga; Carmen Torres; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

7.  Transferable multidrug resistance plasmid carrying cfr associated with tet(L), ant(4')-Ia, and dfrK genes from a clinical methicillin-resistant Staphylococcus aureus ST125 strain.

Authors:  Enrique Ruiz de Gopegui; Carlos Juan; Laura Zamorano; José L Pérez; Antonio Oliver
Journal:  Antimicrob Agents Chemother       Date:  2012-01-03       Impact factor: 5.191

8.  Distribution of the multidrug resistance gene cfr in Staphylococcus species isolates from swine farms in China.

Authors:  Yang Wang; Wanjiang Zhang; Juan Wang; Congming Wu; Zhangqi Shen; Xiao Fu; Yang Yan; Qijing Zhang; Stefan Schwarz; Jianzhong Shen
Journal:  Antimicrob Agents Chemother       Date:  2011-12-19       Impact factor: 5.191

Review 9.  Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic.

Authors:  Michael Z David; Robert S Daum
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132

10.  Emerging multidrug resistance in community-associated Staphylococcus aureus involved in skin and soft tissue infections and nasal colonization.

Authors:  Grace C Lee; Steven D Dallas; Yufeng Wang; Randall J Olsen; Kenneth A Lawson; James Wilson; Christopher R Frei
Journal:  J Antimicrob Chemother       Date:  2017-09-01       Impact factor: 5.790
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