Literature DB >> 16127072

Targeting of the virulence factor acetohydroxyacid synthase by sulfonylureas results in inhibition of intramacrophagic multiplication of Brucella suis.

Rose-Anne Boigegrain1, Jean-Pierre Liautard, Stephan Köhler.   

Abstract

The acetohydroxyacid synthase (AHAS) of Brucella suis can be effectively targeted by the sulfonylureas chlorimuron ethyl and metsulfuron methyl. Growth in minimal medium was inhibited, and multiplication in human macrophages was totally abolished with 100 microM of sulfonylureas. Metsulfuron methyl-resistant mutants showed reduced viability in macrophages and reduced AHAS activity.

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Year:  2005        PMID： 16127072      PMCID： PMC1195390          DOI： 10.1128/AAC.49.9.3922-3925.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Authors:  C M Hill; S S Pang; R G Duggleby
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4.  Isolation and characterization of subunits of acetohydroxy acid synthase isozyme III and reconstitution of the holoenzyme.

Authors:  M Vyazmensky; C Sella; Z Barak; D M Chipman
Journal:  Biochemistry       Date:  1996-08-13       Impact factor: 3.162

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Authors:  S S Pang; R G Duggleby
Journal:  Biochemistry       Date:  1999-04-20       Impact factor: 3.162

6.  Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages.

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Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-18       Impact factor: 11.205

8.  Expression, purification and characterization of Arabidopsis thaliana acetohydroxyacid synthase.

Authors:  A K Chang; R G Duggleby
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Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-23       Impact factor: 11.205

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Authors:  J A Grandoni; P T Marta; J V Schloss
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  6 in total

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2.  FgIlv3a is crucial in branched-chain amino acid biosynthesis, vegetative differentiation, and virulence in Fusarium graminearum.

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4.  Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

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Journal:  BMC Microbiol       Date:  2009-08-20       Impact factor: 3.605
  6 in total

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