Literature DB >> 17698620

Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

Pascale Joseph1, Marie-Rose Abdo, Rose-Anne Boigegrain, Jean-Louis Montero, Jean-Yves Winum, Stephan Köhler.   

Abstract

Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity.

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Year:  2007        PMID： 17698620      PMCID： PMC2043266          DOI： 10.1128/AAC.00572-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Computational modeling of a binding conformation of the intermediate L-histidinal to histidinol dehydrogenase.

Authors:  K Gohda; D Ohta; G Iwasaki; P Ertl; O Jacob
Journal:  J Chem Inf Comput Sci       Date:  2001 Jan-Feb

2.  What is the nature of the replicative niche of a stealthy bug named Brucella?

Authors:  Stephan Köhler; Sylvie Michaux-Charachon; Françoise Porte; Michel Ramuz; Jean Pierre Liautard
Journal:  Trends Microbiol       Date:  2003-05       Impact factor: 17.079

3.  Structural and functional conservation of histidinol dehydrogenase between plants and microbes.

Authors:  A Nagai; E Ward; J Beck; S Tada; J Y Chang; A Scheidegger; J Ryals
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

4.  The nutrition of Brucellae: utilization of single amino acids for growth.

Authors:  P GERHARDT; L A TUCKER; J B WILSON
Journal:  J Bacteriol       Date:  1950-06       Impact factor: 3.490

5.  The intramacrophagic environment of Brucella suis and bacterial response.

Authors:  Stephan Köhler; Françoise Porte; Véronique Jubier-Maurin; Safia Ouahrani-Bettache; Jacques Teyssier; Jean-Pierre Liautard
Journal:  Vet Microbiol       Date:  2002-12-20       Impact factor: 3.293

6.  The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell.

Authors:  Stephan Kohler; Vincent Foulongne; Safia Ouahrani-Bettache; Gisele Bourg; Jacques Teyssier; Michel Ramuz; Jean-Pierre Liautard
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-18       Impact factor: 11.205

Review 7.  From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis.

Authors:  Jacques Godfroid; Axel Cloeckaert; Jean-Pierre Liautard; Stephan Kohler; David Fretin; Karl Walravens; Bruno Garin-Bastuji; Jean-Jacques Letesson
Journal:  Vet Res       Date:  2005 May-Jun       Impact factor: 3.683

8.  Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models.

Authors:  V Foulongne; K Walravens; G Bourg; M L Boschiroli; J Godfroid; M Ramuz; D O'Callaghan
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

9.  Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages.

Authors:  F Porte; J P Liautard; S Köhler
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

10.  Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine.

Authors:  Marie-Rose Abdo; Pascale Joseph; Rose-Anne Boigegrain; Jean-Pierre Liautard; Jean-Louis Montero; Stephan Köhler; Jean-Yves Winum
Journal:  Bioorg Med Chem       Date:  2007-04-24       Impact factor: 3.641
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  3 in total

1.  Transposon Sequencing of Brucella abortus Uncovers Essential Genes for Growth In Vitro and Inside Macrophages.

Authors:  Jean-François Sternon; Pierre Godessart; Rosa Gonçalves de Freitas; Mathilde Van der Henst; Katy Poncin; Nayla Francis; Kevin Willemart; Matthias Christen; Beat Christen; Jean-Jacques Letesson; Xavier De Bolle
Journal:  Infect Immun       Date:  2018-07-23       Impact factor: 3.441

Review 2.  Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

Authors:  Stephan Köhler; Safia Ouahrani-Bettache; Jean-Yves Winum
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

3.  Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals.

Authors:  Fei Su; Ping Xu
Journal:  Sci Rep       Date:  2014-01-29       Impact factor: 4.379
  3 in total

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