Literature DB >> 16127071

Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi.

Alisa P Alker1, Victor Mwapasa, Anne Purfield, Stephen J Rogerson, Malcolm E Molyneux, Deborah D Kamwendo, Eyob Tadesse, Ebbie Chaluluka, Steven R Meshnick.   

Abstract

We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

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Year:  2005        PMID： 16127071      PMCID： PMC1195417          DOI： 10.1128/AAC.49.9.3919-3921.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Prevalence of pfcrt mutations in Congolese and Malawian Plasmodium falciparum isolates as determined by a new Taqman assay.

Authors:  Paul E Wilson; Walter Kazadi; Deborah Demster Kamwendo; Victor Mwapasa; Anne Purfield; Steven R Meshnick
Journal:  Acta Trop       Date:  2005-01       Impact factor: 3.112

2.  Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance.

Authors:  C V Plowe; J F Cortese; A Djimde; O C Nwanyanwu; W M Watkins; P A Winstanley; J G Estrada-Franco; R E Mollinedo; J C Avila; J L Cespedes; D Carter; O K Doumbo
Journal:  J Infect Dis       Date:  1997-12       Impact factor: 5.226

3.  Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.

Authors:  J Sulo; P Chimpeni; J Hatcher; J G Kublin; C V Plowe; M E Molyneux; K Marsh; T E Taylor; W M Watkins; P A Winstanley
Journal:  Lancet       Date:  2002-10-12       Impact factor: 79.321

4.  Prevalence of point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from India and Thailand: a molecular epidemiologic study.

Authors:  S Biswas; A Escalante; S Chaiyaroj; P Angkasekwinai; A A Lal
Journal:  Trop Med Int Health       Date:  2000-10       Impact factor: 2.622

5.  Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

Authors:  S J Foote; D Galatis; A F Cowman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Polyclonal Plasmodium falciparum malaria in travelers and selection of antifolate mutations after proguanil prophylaxis.

Authors:  Anna Färnert; Karolin Tengstam; Ingela Berggren Palme; Ulf Bronner; Marianne Lebbad; Göte Swedberg; Anders Björkman
Journal:  Am J Trop Med Hyg       Date:  2002-05       Impact factor: 2.345

7.  Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania.

Authors:  Michele D Hastings; Sarah J Bates; Eric A Blackstone; Stephanie M Monks; Theonest K Mutabingwa; Carol Hopkins Sibley
Journal:  Trans R Soc Trop Med Hyg       Date:  2002 Nov-Dec       Impact factor: 2.184

8.  Plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of Lao PDR.

Authors:  Nicole Berens; Babett Schwoebel; Sabine Jordan; Viengxay Vanisaveth; Rattanaxay Phetsouvanh; Eva-Maria Christophel; Samlane Phompida; Tomas Jelinek
Journal:  Trop Med Int Health       Date:  2003-09       Impact factor: 2.622

9.  Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.

Authors:  James G Kublin; Joseph F Cortese; Eric Mbindo Njunju; Rabia A G Mukadam; Jack J Wirima; Peter N Kazembe; Abdoulaye A Djimdé; Bourema Kouriba; Terrie E Taylor; Christopher V Plowe
Journal:  J Infect Dis       Date:  2003-05-21       Impact factor: 5.226

10.  High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi.

Authors:  B Bwijo; A Kaneko; M Takechi; I L Zungu; Y Moriyama; J K Lum; T Tsukahara; T Mita; N Takahashi; Y Bergqvist; A Björkman; T Kobayakawa
Journal:  Acta Trop       Date:  2003-03       Impact factor: 3.112
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  32 in total

1.  Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes.

Authors:  Sungano Mharakurwa; Taida Kumwenda; Mtawa A P Mkulama; Mulenga Musapa; Sandra Chishimba; Clive J Shiff; David J Sullivan; Philip E Thuma; Kun Liu; Peter Agre
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-07       Impact factor: 11.205

2.  Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.

Authors:  Edwin Ochong; David J Bell; David J Johnson; Umberto D'Alessandro; Modest Mulenga; Sant Muangnoicharoen; Jean-Pierre Van Geertruyden; Peter A Winstanley; Patrick G Bray; Stephen A Ward; Andrew Owen
Journal:  Antimicrob Agents Chemother       Date:  2008-08-25       Impact factor: 5.191

3.  Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa.

Authors:  Alisa P Alker; Jonathan J Juliano; Steven R Meshnick; Andrew Owen; Edwin Ochong; David J Bell; David J Johnson; Umberto d'Alessandro; Modest Mulenga; Sant Muangnoicharoen; J P Van Geertruyden; Peter A Winstanley; Patrick G Bray; Stephen A Ward
Journal:  Antimicrob Agents Chemother       Date:  2009-04       Impact factor: 5.191

4.  dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo.

Authors:  Alisa P Alker; Walter M Kazadi; Albert K Kutelemeni; Peter B Bloland; Antoinette K Tshefu; Steven R Meshnick
Journal:  Trop Med Int Health       Date:  2008-11       Impact factor: 2.622

5.  Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates.

Authors:  Sabelo V Dlamini; Khalid Beshir; Colin J Sutherland
Journal:  Malar J       Date:  2010-03-03       Impact factor: 2.979

6.  Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets.

Authors:  Gaoqian Feng; Julie A Simpson; Ebbie Chaluluka; Malcolm E Molyneux; Stephen J Rogerson
Journal:  PLoS One       Date:  2010-08-06       Impact factor: 3.240

7.  Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance.

Authors:  Anne F Gasasira; Moses R Kamya; Edwin O Ochong; Neil Vora; Jane Achan; Edwin Charlebois; Theodore Ruel; Fredrick Kateera; Denise N Meya; Diane Havlir; Philip J Rosenthal; Grant Dorsey
Journal:  Malar J       Date:  2010-06-23       Impact factor: 2.979

8.  Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women.

Authors:  Anne-Maria Rantala; Steve M Taylor; Paul A Trottman; Mari Luntamo; Bernard Mbewe; Kenneth Maleta; Teija Kulmala; Per Ashorn; Steven R Meshnick
Journal:  Malar J       Date:  2010-10-06       Impact factor: 2.979

9.  Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.

Authors:  Mayke J A M Oesterholt; Michael Alifrangis; Colin J Sutherland; Sabah A Omar; Patrick Sawa; Christina Howitt; Louis C Gouagna; Robert W Sauerwein; Teun Bousema
Journal:  PLoS One       Date:  2009-02-05       Impact factor: 3.240

10.  Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial.

Authors:  Elizabeth N Allen; Francesca Little; Tunisio Camba; Yasmin Cassam; Jaishree Raman; Andrew Boulle; Karen I Barnes
Journal:  Malar J       Date:  2009-06-26       Impact factor: 2.979
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