Literature DB >> 12630380

Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania.

Michele D Hastings1, Sarah J Bates, Eric A Blackstone, Stephanie M Monks, Theonest K Mutabingwa, Carol Hopkins Sibley.   

Abstract

In 2000 we used a sensitive technique to examine 9 isolates from malaria patients in Muheza, Tanzania who had failed treatment with sulfadoxine-pyrimethamine (SP). Three isolates carried, at low levels, the leucine to isoleucine change at amino acid 164 that is associated with clinical failure of SP. Numerous other highly resistant alleles were also observed.

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Year:  2002        PMID： 12630380     DOI： 10.1016/s0035-9203(02)90349-4

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  18 in total

Review 1.  History, dynamics, and public health importance of malaria parasite resistance.

Authors:  Ambrose O Talisuna; Peter Bloland; Umberto D'Alessandro
Journal:  Clin Microbiol Rev       Date:  2004-01       Impact factor: 26.132

2.  Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi.

Authors:  Alisa P Alker; Victor Mwapasa; Anne Purfield; Stephen J Rogerson; Malcolm E Molyneux; Deborah D Kamwendo; Eyob Tadesse; Ebbie Chaluluka; Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

3.  Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations.

Authors:  Christopher Ma; Johnson Tran; Catherine Li; Lakshmi Ganesan; David Wood; Naomi Morrissette
Journal:  Genetics       Date:  2008-09-09       Impact factor: 4.562

4.  Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro.

Authors:  Conner I Sandefur; Jason M Wooden; Isaac K Quaye; Worachart Sirawaraporn; Carol Hopkins Sibley
Journal:  Mol Biochem Parasitol       Date:  2007-03-20       Impact factor: 1.759

5.  Detection of the dihydrofolate reductase-164L mutation in Plasmodium falciparum infections from Malawi by heteroduplex tracking assay.

Authors:  Jonathan J Juliano; Paul Trottman; Victor Mwapasa; Steven R Meshnick
Journal:  Am J Trop Med Hyg       Date:  2008-06       Impact factor: 2.345

6.  In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.

Authors:  Steven M Kiara; John Okombo; Victor Masseno; Leah Mwai; Isabella Ochola; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191

7.  In vitro susceptibility to pyrimethamine of DHFR I164L single mutant Plasmodium falciparum.

Authors:  Valérie Andriantsoanirina; Rémy Durand; Bruno Pradines; Eric Baret; Christiane Bouchier; Arsène Ratsimbasoa; Didier Ménard
Journal:  Malar J       Date:  2011-09-27       Impact factor: 2.979

8.  Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples.

Authors:  Yumiko Saito-Nakano; Kazuyuki Tanabe; Toshihiro Mita
Journal:  Malar J       Date:  2011-12-31       Impact factor: 2.979

9.  Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.

Authors:  Mayke J A M Oesterholt; Michael Alifrangis; Colin J Sutherland; Sabah A Omar; Patrick Sawa; Christina Howitt; Louis C Gouagna; Robert W Sauerwein; Teun Bousema
Journal:  PLoS One       Date:  2009-02-05       Impact factor: 3.240

10.  Dihydrofolate reductase I164L mutation in Plasmodium falciparum, Madagascar.

Authors:  Didier Ménard; Valérie Andriantsoanirina; Martial Jahevitra; Céline Barnadas; Magali Tichit; Christiane Bouchier; Carol Hopkins Sibley
Journal:  Emerg Infect Dis       Date:  2008-07       Impact factor: 6.883
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