Literature DB >> 16113721

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2'-amino-alpha-l-LNA.

Patrick J Hrdlicka1, T Santhosh Kumar, Jesper Wengel.   

Abstract

Incorporation of a single pyrene-functionalized 2'-amino-alpha-l-LNA monomer X into short DNA strands induces extraordinarily high binding affinity towards complementary DNA (up to 16 degrees C increase per modification), whereas labile duplexes, suitable as probes for targeting of double stranded DNA, are formed upon positioning of two monomers X in an interstrand +1 zipper motif.

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Year:  2005        PMID： 16113721     DOI： 10.1039/b506986f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes.

Authors:  Dale C Guenther; Raymond G Emehiser; Allison Inskeep; Saswata Karmakar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2020-06-24       Impact factor: 3.876

2.  Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

Authors:  Sujay P Sau; Pawan Kumar; Brooke A Anderson; Michael E Østergaard; Lee Deobald; Andrzej Paszczynski; Pawan K Sharma; Patrick J Hrdlicka
Journal:  Chem Commun (Camb)       Date:  2009-10-12       Impact factor: 6.222

3.  Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers.

Authors:  Saswata Karmakar; Andreas S Madsen; Dale C Guenther; Bradley C Gibbons; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2014-08-21       Impact factor: 3.876

Review 4.  Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

Authors:  Michael E Østergaard; Patrick J Hrdlicka
Journal:  Chem Soc Rev       Date:  2011-04-13       Impact factor: 54.564

5.  Invader LNA: efficient targeting of short double stranded DNA.

Authors:  Sujay P Sau; T Santhosh Kumar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2010-03-04       Impact factor: 3.876

6.  Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridine.

Authors:  Brooke A Anderson; Patrick J Hrdlicka
Journal:  Bioorg Med Chem Lett       Date:  2015-07-07       Impact factor: 2.823

7.  Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers.

Authors:  Saswata Karmakar; Dale C Guenther; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2013-11-20       Impact factor: 4.354

8.  Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

Authors:  T Santhosh Kumar; Andreas S Madsen; Michael E Østergaard; Sujay P Sau; Jesper Wengel; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2009-02-06       Impact factor: 4.354

9.  Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides.

Authors:  Bradley A Didion; Saswata Karmakar; Dale C Guenther; Sujay P Sau; John P Verstegen; Patrick J Hrdlicka
Journal:  Chembiochem       Date:  2013-08-23       Impact factor: 3.164

10.  Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens.

Authors:  Benjamin Denn; Saswata Karmakar; Dale C Guenther; Patrick J Hrdlicka
Journal:  Chem Commun (Camb)       Date:  2013-10-28       Impact factor: 6.222
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