Literature DB >> 19885469

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.

Sujay P Sau1, Pawan Kumar, Brooke A Anderson, Michael E Østergaard, Lee Deobald, Andrzej Paszczynski, Pawan K Sharma, Patrick J Hrdlicka.   

Abstract

Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3?-exonucleases.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19885469      PMCID： PMC2846108          DOI： 10.1039/b917312a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  27 in total

1.  C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability.

Authors:  Michael E Østergaard; Pawan Kumar; Bharat Baral; Daniel J Raible; T Santhosh Kumar; Brooke A Anderson; Dale C Guenther; Lee Deobald; Andrzej J Paszczynski; Pawan K Sharma; Patrick J Hrdlicka
Journal:  Chembiochem       Date:  2009-11-23       Impact factor: 3.164

2.  5-(1-propargylamino)-2'-deoxyuridine (UP): a novel thymidine analogue for generating DNA triplexes with increased stability.

Authors:  J Bijapur; M D Keppler; S Bergqvist; T Brown; K R Fox
Journal:  Nucleic Acids Res       Date:  1999-04-15       Impact factor: 16.971

3.  Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.

Authors:  Matthieu Sollogoub; Richard A J Darby; Bernard Cuenoud; Tom Brown; Keith R Fox
Journal:  Biochemistry       Date:  2002-06-11       Impact factor: 3.162

4.  Triplex formation with 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) having C3'-endo conformation at physiological pH.

Authors:  Makoto Koizumi; Koji Morita; Makiko Daigo; Shinya Tsutsumi; Koji Abe; Satoshi Obika; Takeshi Imanishi
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

5.  2'-O,4'-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: thermodynamic and kinetic studies.

Authors:  H Torigoe; Y Hari; M Sekiguchi; S Obika; T Imanishi
Journal:  J Biol Chem       Date:  2000-10-16       Impact factor: 5.157

6.  Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting.

Authors:  L Lacroix; J Lacoste; J F Reddoch; J L Mergny; D D Levy; M M Seidman; M D Matteucci; P M Glazer
Journal:  Biochemistry       Date:  1999-02-09       Impact factor: 3.162

Review 7.  Development of bridged nucleic acid analogues for antigene technology.

Authors:  Satoshi Obika
Journal:  Chem Pharm Bull (Tokyo)       Date:  2004-12       Impact factor: 1.645

8.  Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: physical chemistry, biochemistry, and modeling studies.

Authors:  Bei-Wen Sun; B Ravindra Babu; Mads D Sørensen; Krystyna Zakrzewska; Jesper Wengel; Jian-Sheng Sun
Journal:  Biochemistry       Date:  2004-04-13       Impact factor: 3.162

9.  Kinetic analysis of triple-helix formation by pyrimidine oligodeoxynucleotides and duplex DNA.

Authors:  L E Xodo
Journal:  Eur J Biochem       Date:  1995-03-15

10.  Poly(pyrimidine) . poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH.

Authors:  J S Lee; M L Woodsworth; L J Latimer; A R Morgan
Journal:  Nucleic Acids Res       Date:  1984-08-24       Impact factor: 16.971
View more
  4 in total

1.  Sensitive Fluorescent Sensor for Recognition of HIV-1 dsDNA by Using Glucose Oxidase and Triplex DNA.

Authors:  Yubin Li; Sheng Liu; Liansheng Ling
Journal:  J Anal Methods Chem       Date:  2018-04-01       Impact factor: 2.193

2.  Invader LNA: efficient targeting of short double stranded DNA.

Authors:  Sujay P Sau; T Santhosh Kumar; Patrick J Hrdlicka
Journal:  Org Biomol Chem       Date:  2010-03-04       Impact factor: 3.876

3.  Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes.

Authors:  Sylvain Geny; Pedro M D Moreno; Tomasz Krzywkowski; Olof Gissberg; Nicolai K Andersen; Abdirisaq J Isse; Amro M El-Madani; Chenguang Lou; Y Vladimir Pabon; Brooke A Anderson; Eman M Zaghloul; Rula Zain; Patrick J Hrdlicka; Per T Jørgensen; Mats Nilsson; Karin E Lundin; Erik B Pedersen; Jesper Wengel; C I Edvard Smith
Journal:  Nucleic Acids Res       Date:  2016-02-08       Impact factor: 16.971

4.  Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs.

Authors:  Sujay P Sau; Pawan Kumar; Pawan K Sharma; Patrick J Hrdlicka
Journal:  Nucleic Acids Res       Date:  2012-08-01       Impact factor: 16.971
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.