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Literature DB >> 16113715

The enzymology of clavam and carbapenem biosynthesis.

Nadia J Kershaw¹, Matthew E C Caines, Mark C Sleeman, Christopher J Schofield.

Abstract

The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 16113715 DOI： 10.1039/b505964j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

20 in total

1. O(2)-evolving chlorite dismutase as a tool for studying O(2)-utilizing enzymes.

Authors: Laura M K Dassama; Timothy H Yosca; Denise A Conner; Michael H Lee; Béatrice Blanc; Bennett R Streit; Michael T Green; Jennifer L DuBois; Carsten Krebs; J Martin Bollinger
Journal: Biochemistry Date: 2012-02-13 Impact factor: 3.162

2. Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase.

Authors: Mary L Raber; Michael F Freeman; Craig A Townsend
Journal: J Biol Chem Date: 2008-10-27 Impact factor: 5.157

Review 3. Freeze-quench (57)Fe-Mössbauer spectroscopy: trapping reactive intermediates.

Authors: Carsten Krebs; J Martin Bollinger
Journal: Photosynth Res Date: 2009 Nov-Dec Impact factor: 3.573

4. Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase.

Authors: Esta Tamanaha; Bo Zhang; Yisong Guo; Wei-Chen Chang; Eric W Barr; Gang Xing; Jennifer St Clair; Shengfa Ye; Frank Neese; J Martin Bollinger; Carsten Krebs
Journal: J Am Chem Soc Date: 2016-07-05 Impact factor: 15.419

Review 5. Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.

Authors: John A Hangasky; Cornelius Y Taabazuing; Meaghan A Valliere; Michael J Knapp
Journal: Metallomics Date: 2013-04 Impact factor: 4.526

6. A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

Authors: Mary L Raber; Alvaro Castillo; Alexander Greer; Craig A Townsend
Journal: Chembiochem Date: 2009-12-14 Impact factor: 3.164

The enzymology of clavam and carbapenem biosynthesis.

1. O(2)-evolving chlorite dismutase as a tool for studying O(2)-utilizing enzymes.

2. Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase.

Review 3. Freeze-quench (57)Fe-Mössbauer spectroscopy: trapping reactive intermediates.

4. Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase.

Review 5. Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.

6. A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

7. Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis.

Review 8. Antibiotics from microbes: converging to kill.

9. Novel Approaches for the Accumulation of Oxygenated Intermediates to Multi-Millimolar Concentrations.

Review 10. Versatility of biological non-heme Fe(II) centers in oxygen activation reactions.