| Literature DB >> 16106382 |
Nobuaki Egashira1, Katsunori Iwasaki, Yuki Akiyoshi, Yuki Takagaki, Izzettin Hatip-Al-Khatib, Kenichi Mishima, Kouji Kurauchi, Tomoaki Ikeda, Michihiro Fujiwara.
Abstract
Amyloid beta protein (Abeta) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Abeta25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Abeta25-35 at 10 microM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 microg/mL significantly reduced the Abeta25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Abeta25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD. Copyright (c) 2005 John Wiley & Sons, Ltd.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16106382 DOI： 10.1002/ptr.1671
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878