Literature DB >> 27493835

Danggui-Shaoyao-San: New Hope for Alzheimer's Disease.

Xin Fu1, QiuHong Wang1, ZhiBin Wang1, HaiXue Kuang1, Pinghui Jiang2.   

Abstract

Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyak-san (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum chuanxiong Hort., Paeonia lactiflora pall., Poria cocos (Schw.) Wolf, Alisma orientalis (Sam.) Juzep., Atractylodes macrocephala Koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. Recent studies show that DSS has an effect on free radical-mediated neurological diseases and exhibits anti-inflammatory and antioxidant activities and reduces cell apoptosis in the hippocampus. In addition, DSS mediates the modulation of central monoamine neurotransmitter systems and ameliorates dysfunction of the central cholinergic nervous system and scopolamine-induced decrease in ACh levels. DSS improves the function of the dopaminergic, adrenergic, and serotonergic nervous systems. Interestingly, DSS can alleviate cognitive dysfunction of Alzheimer's disease (AD) patients, suggesting that it is a useful therapeutic agent for AD. This paper reviews the mechanism of DSS for the treatment of AD.

Entities:  

Keywords:  Alzheimer's disease; Danggui-Shaoyao-San; anti-inflammation; antioxidant activity; cell apoptosis

Year:  2015        PMID： 27493835      PMCID： PMC4963193          DOI： 10.14336/AD.2015.1220

Source DB:  PubMed          Journal:  Aging Dis        ISSN： 2152-5250            Impact factor:   6.745


  97 in total

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Authors:  Yurinosuke Kitabayashi; Keisuke Shibata; Takashi Nakamae; Jin Narumoto; Kenji Fukui
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3.  Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity.

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Journal:  Curr Alzheimer Res       Date:  2015       Impact factor: 3.498

4.  ASICs mediate the modulatory effect by paeoniflorin on α-synuclein autophagic degradation.

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Journal:  Brain Res       Date:  2011-04-13       Impact factor: 3.252

5.  Paeoniflorin Atttenuates Amyloidogenesis and the Inflammatory Responses in a Transgenic Mouse Model of Alzheimer's Disease.

Authors:  Hong-Ri Zhang; Jing-Hua Peng; Xiao-Bing Cheng; Bao-Zhong Shi; Mao-Ying Zhang; Ru-Xiang Xu
Journal:  Neurochem Res       Date:  2015-06-12       Impact factor: 3.996

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Journal:  Toxicol In Vitro       Date:  2012-01-17       Impact factor: 3.500

7.  Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity.

Authors:  Stéphane Bastianetto; Zhi-Xing Yao; Vassilios Papadopoulos; Rémi Quirion
Journal:  Eur J Neurosci       Date:  2006-01       Impact factor: 3.386

8.  Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes.

Authors:  Ran Choi; Bo Hwan Kim; Jarinyaporn Naowaboot; Mi Young Lee; Mi Ri Hyun; Eun Ju Cho; Eun Soo Lee; Eun Young Lee; Young Chul Yang; Choon Hee Chung
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9.  Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.

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Journal:  Planta Med       Date:  2006-04       Impact factor: 3.352

10.  Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol.

Authors:  Yan Huang; Zeng-Yao Hu; Hui Yuan; Lei Shu; Gang Liu; Shan-Yi Qiao; Lei Sun; Wen-Xia Zhou; Yong-Xiang Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2014-03-16       Impact factor: 2.629
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  16 in total

Review 1.  Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease.

Authors:  Sravan Gopalkrishnashetty Sreenivasmurthy; Jing-Yi Liu; Ju-Xian Song; Chuan-Bin Yang; Sandeep Malampati; Zi-Ying Wang; Ying-Yu Huang; Min Li
Journal:  Int J Mol Sci       Date:  2017-01-28       Impact factor: 5.923

2.  Application of Feedback System Control Optimization Technique in Combined Use of Dual Antiplatelet Therapy and Herbal Medicines.

Authors:  Wang Liu; Yu-Long Li; Mu-Ting Feng; Yu-Wei Zhao; Xianting Ding; Ben He; Xuan Liu
Journal:  Front Physiol       Date:  2018-05-04       Impact factor: 4.566

3.  Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway.

Authors:  Yangyang Zhou; Hongxun Tao; Anqi Wang; Zhangfeng Zhong; Xu Wu; Mei Wang; Zhaoxiang Bian; Shengpeng Wang; Yitao Wang
Journal:  Chin Med       Date:  2019-01-29       Impact factor: 5.455

Review 4.  Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis.

Authors:  Yanjie Zhang; Kyoungmin Noh; Wook Song
Journal:  Integr Med Res       Date:  2019-04-22

Review 5.  Traditional Oriental Medicines and Alzheimer's Disease.

Authors:  Seong Gak Jeon; Eun Ji Song; Dongje Lee; Junyong Park; Yunkwon Nam; Jin-Il Kim; Minho Moon
Journal:  Aging Dis       Date:  2019-04-01       Impact factor: 6.745

6.  Danggui-Shaoyao-San for dementia: A PRISMA-compliant systematic review and meta-analysis.

Authors:  Yunna Kim; Seung-Hun Cho
Journal:  Medicine (Baltimore)       Date:  2020-01       Impact factor: 1.817

7.  In-depth transcriptomic analyses of LncRNA and mRNA expression in the hippocampus of APP/PS1 mice by Danggui-Shaoyao-San.

Authors:  Zhenyan Song; Fuzhou Li; Chunxiang He; Jingping Yu; Ping Li; Ze Li; Miao Yang; Shaowu Cheng
Journal:  Aging (Albany NY)       Date:  2020-11-18       Impact factor: 5.682

8.  Danggwijagyaksan for climacteric syndrome in peri- and postmenopausal women with a blood-deficiency dominant pattern: study protocol for a randomized, double-blind, placebo-controlled pilot trial.

Authors:  Mikyung Kim; Ae-Ran Kim; Hyo-Ju Park; Ojin Kwon; Joo-Hee Kim; Eun-Ji Park; Seon-Eun Baek; Jeong-Eun Yoo; Jun-Hwan Lee
Journal:  Trials       Date:  2018-01-15       Impact factor: 2.279

Review 9.  Ginseng: An Nonnegligible Natural Remedy for Healthy Aging.

Authors:  Yong Yang; Changhong Ren; Yuan Zhang; XiaoDan Wu
Journal:  Aging Dis       Date:  2017-12-01       Impact factor: 6.745

10.  Traditional Chinese medicine Danggui Shaoyao San for the treatment of Alzheimer's disease: A Protocol for Systematic Review.

Authors:  Yu You; Xinglong Liu; Yanyan You; Dan Liu; Chunjiang Zhang; Yunhui Chen; Tiane Zhang
Journal:  Medicine (Baltimore)       Date:  2020-04       Impact factor: 1.817
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