BACKGROUND AND AIMS: Metabolic syndrome (MS) consists of a cluster of diseases, including obesity, dyslipidemia, hyperglycemia and high blood pressure. The purpose of the present study was to assess the association of MS with adenomas of the rectosigmoid colon, a well-established precancerous lesion. METHODS: A total of 4938 Taiwanese patients (2891 men and 2047 women with a mean age of 50.1 years), who had a physical examination at our hospital between January 2001 and October 2002, were enrolled in this study. All patients underwent a sigmoidoscopic examination to 60 cm from the anus. A modified National Cholesterol Education Program (NCEP) definition of MS was used in this study, in which body mass index (BMI) was substituted for the waist circumference measurement. RESULTS: Overall, 14% of patients had an elevated fasting glucose, 27% had high blood pressure, 14% had an increased triglyceride (TG) level, 8% had low high density lipoprotein (HDL) cholesterol, and 18% were obese. Rectosigmoid polyps were present in 17% of patients, among whom 568 received polypectomy. Pathological findings were hyperplastic in 138 subjects, adenomas in 341, carcinomas in 10, and other benign lesions in 79. In patients without polyps, the adjusted mean TG level and calculated BMI level were lower than those in patients with adenomas. No such difference existed, however, between patients without polyps and those with hyperplastic polyps. The odds ratio of adenomas in situ as compared to either a polyp-free state or the presence of hyperplastic polyps increased significantly with the number of MS diagnostic criteria the patient exhibited. CONCLUSION: Our study shows that MS is associated with rectosigmoid adenomas in a Chinese population. In patients with rectosigmoid polyps, the coexistence of MS may portend an increased risk of adenomas. Copyright 2005 Blackwell Publishing Asia Pty Ltd.
BACKGROUND AND AIMS: Metabolic syndrome (MS) consists of a cluster of diseases, including obesity, dyslipidemia, hyperglycemia and high blood pressure. The purpose of the present study was to assess the association of MS with adenomas of the rectosigmoid colon, a well-established precancerous lesion. METHODS: A total of 4938 Taiwanese patients (2891 men and 2047 women with a mean age of 50.1 years), who had a physical examination at our hospital between January 2001 and October 2002, were enrolled in this study. All patients underwent a sigmoidoscopic examination to 60 cm from the anus. A modified National Cholesterol Education Program (NCEP) definition of MS was used in this study, in which body mass index (BMI) was substituted for the waist circumference measurement. RESULTS: Overall, 14% of patients had an elevated fasting glucose, 27% had high blood pressure, 14% had an increased triglyceride (TG) level, 8% had low high density lipoprotein (HDL) cholesterol, and 18% were obese. Rectosigmoid polyps were present in 17% of patients, among whom 568 received polypectomy. Pathological findings were hyperplastic in 138 subjects, adenomas in 341, carcinomas in 10, and other benign lesions in 79. In patients without polyps, the adjusted mean TG level and calculated BMI level were lower than those in patients with adenomas. No such difference existed, however, between patients without polyps and those with hyperplastic polyps. The odds ratio of adenomas in situ as compared to either a polyp-free state or the presence of hyperplastic polyps increased significantly with the number of MS diagnostic criteria the patient exhibited. CONCLUSION: Our study shows that MS is associated with rectosigmoid adenomas in a Chinese population. In patients with rectosigmoid polyps, the coexistence of MS may portend an increased risk of adenomas. Copyright 2005 Blackwell Publishing Asia Pty Ltd.
Authors: Konstantinos K Tsilidis; Frederick L Brancati; Michael N Pollak; Nader Rifai; Sandra L Clipp; Judith Hoffman-Bolton; Kathy J Helzlsouer; Elizabeth A Platz Journal: Cancer Causes Control Date: 2009-09-23 Impact factor: 2.506
Authors: Michael F Leitzmann; Andrew Flood; Leah M Ferrucci; Philip Schoenfeld; Brooks Cash; Arthur Schatzkin; Amanda J Cross Journal: Cancer Causes Control Date: 2009-04-22 Impact factor: 2.506