AIM: To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis. METHODS: Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The relation between COX-2 expression and prognosis was investigated in 195 cases. RESULTS: The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w = 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2 tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2 expression was significantly related to histological type, lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against Cancer TNM stage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However, there was no significant correlation between COX-2 immunoreactivity and prognosis. CONCLUSION: COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis.
AIM: To investigate the expression of cyclooxygenase-2 (COX-2) in gastric cancer and its relation with the liver metastasis and prognosis. METHODS: Expression of COX-2 mRNA and protein was examined in gastric cancer and its paired substantial normal tissue by semi-quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The relation between COX-2 expression and prognosis was investigated in 195 cases. RESULTS: The expression of COX-2 mRNA in gastric cancer tissue was significantly higher than that in normal tissue in 47 cases (w = 792, P<0.01). The COX-2 mRNA in pT3-4 tissue expressed higher than that in pT1-2 tissue (w = 204, P<0.05). The positive expression rate of COX-2 protein was 57.9% (113/195). The COX-2 expression was significantly related to histological type, lymphnode metastasis, venous invasion and liver metastasis (P<0.05). No relation was found between COX-2 expression and invasion depth, peritoneal metastasis and International Union against CancerTNM stage. The multiple regression analysis showed that the COX-2 expression and venous invasion were obviously associated with liver metastasis (P<0.05). However, there was no significant correlation between COX-2 immunoreactivity and prognosis. CONCLUSION:COX-2 may play an important role in the development of gastric cancer, and the over-expression of COX-2 protein may be a high risk factor for liver metastasis.
Authors: D C Farrow; T L Vaughan; P D Hansten; J L Stanford; H A Risch; M D Gammon; W H Chow; R Dubrow; H Ahsan; S T Mayne; J B Schoenberg; A B West; H Rotterdam; J F Fraumeni; W J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 1998-02 Impact factor: 4.254
Authors: O N Tucker; A J Dannenberg; E K Yang; F Zhang; L Teng; J M Daly; R A Soslow; J L Masferrer; B M Woerner; A T Koki; T J Fahey Journal: Cancer Res Date: 1999-03-01 Impact factor: 12.701
Authors: H Sano; Y Kawahito; R L Wilder; A Hashiramoto; S Mukai; K Asai; S Kimura; H Kato; M Kondo; T Hla Journal: Cancer Res Date: 1995-09-01 Impact factor: 12.701
Authors: Paulo R C Almeida; Francisco V A Ferreira; Cássio C Santos; Francisco D Rocha-Filho; Raul R R P Feitosa; Esther A A Falcão; Belise K Cavada; Roberto C P Lima-Júnior; Ronaldo A Ribeiro Journal: World J Gastroenterol Date: 2012-02-28 Impact factor: 5.742
Authors: Agnieszka Smolinska; Kerstin Singer; Janine Golchert; Urszula Smyczynska; Wojciech Fendler; Matthias Sendler; Jens van den Brandt; Stephan Singer; Georg Homuth; Markus M Lerch; Patryk Moskwa Journal: Cancers (Basel) Date: 2022-08-23 Impact factor: 6.575